Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Detalhes bibliográficos
Autor(a) principal: Luna,R.C.P.
Data de Publicação: 2018
Outros Autores: de Oliveira,Y., Lisboa,J.V.C., Chaves,T.R., de Araújo,T.A.M., de Sousa,E.E., Miranda Neto,M., Pirola,L., Braga,V.A., de Brito Alves,J.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301
Resumo: Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.
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spelling Insights on the epigenetic mechanisms underlying pulmonary arterial hypertensionEpigeneticPulmonary arterial hypertensionDNA MethylationHistone acetylationmiRNAsPulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.Associação Brasileira de Divulgação Científica2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301Brazilian Journal of Medical and Biological Research v.51 n.12 2018reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20187437info:eu-repo/semantics/openAccessLuna,R.C.P.de Oliveira,Y.Lisboa,J.V.C.Chaves,T.R.de Araújo,T.A.M.de Sousa,E.E.Miranda Neto,M.Pirola,L.Braga,V.A.de Brito Alves,J.L.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2018001200301Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
spellingShingle Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
Luna,R.C.P.
Epigenetic
Pulmonary arterial hypertension
DNA Methylation
Histone acetylation
miRNAs
title_short Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_full Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_fullStr Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_full_unstemmed Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
title_sort Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
author Luna,R.C.P.
author_facet Luna,R.C.P.
de Oliveira,Y.
Lisboa,J.V.C.
Chaves,T.R.
de Araújo,T.A.M.
de Sousa,E.E.
Miranda Neto,M.
Pirola,L.
Braga,V.A.
de Brito Alves,J.L.
author_role author
author2 de Oliveira,Y.
Lisboa,J.V.C.
Chaves,T.R.
de Araújo,T.A.M.
de Sousa,E.E.
Miranda Neto,M.
Pirola,L.
Braga,V.A.
de Brito Alves,J.L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Luna,R.C.P.
de Oliveira,Y.
Lisboa,J.V.C.
Chaves,T.R.
de Araújo,T.A.M.
de Sousa,E.E.
Miranda Neto,M.
Pirola,L.
Braga,V.A.
de Brito Alves,J.L.
dc.subject.por.fl_str_mv Epigenetic
Pulmonary arterial hypertension
DNA Methylation
Histone acetylation
miRNAs
topic Epigenetic
Pulmonary arterial hypertension
DNA Methylation
Histone acetylation
miRNAs
description Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x20187437
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.51 n.12 2018
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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