Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301 |
Resumo: | Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH. |
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Brazilian Journal of Medical and Biological Research |
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Insights on the epigenetic mechanisms underlying pulmonary arterial hypertensionEpigeneticPulmonary arterial hypertensionDNA MethylationHistone acetylationmiRNAsPulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH.Associação Brasileira de Divulgação Científica2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301Brazilian Journal of Medical and Biological Research v.51 n.12 2018reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20187437info:eu-repo/semantics/openAccessLuna,R.C.P.de Oliveira,Y.Lisboa,J.V.C.Chaves,T.R.de Araújo,T.A.M.de Sousa,E.E.Miranda Neto,M.Pirola,L.Braga,V.A.de Brito Alves,J.L.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2018001200301Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension |
title |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension |
spellingShingle |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension Luna,R.C.P. Epigenetic Pulmonary arterial hypertension DNA Methylation Histone acetylation miRNAs |
title_short |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension |
title_full |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension |
title_fullStr |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension |
title_full_unstemmed |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension |
title_sort |
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension |
author |
Luna,R.C.P. |
author_facet |
Luna,R.C.P. de Oliveira,Y. Lisboa,J.V.C. Chaves,T.R. de Araújo,T.A.M. de Sousa,E.E. Miranda Neto,M. Pirola,L. Braga,V.A. de Brito Alves,J.L. |
author_role |
author |
author2 |
de Oliveira,Y. Lisboa,J.V.C. Chaves,T.R. de Araújo,T.A.M. de Sousa,E.E. Miranda Neto,M. Pirola,L. Braga,V.A. de Brito Alves,J.L. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Luna,R.C.P. de Oliveira,Y. Lisboa,J.V.C. Chaves,T.R. de Araújo,T.A.M. de Sousa,E.E. Miranda Neto,M. Pirola,L. Braga,V.A. de Brito Alves,J.L. |
dc.subject.por.fl_str_mv |
Epigenetic Pulmonary arterial hypertension DNA Methylation Histone acetylation miRNAs |
topic |
Epigenetic Pulmonary arterial hypertension DNA Methylation Histone acetylation miRNAs |
description |
Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Recent and relevant studies have demonstrated that epigenetic processes may exert key influences on the pathogenesis of PAH and may be promising therapeutic targets in the prevention and/or cure of this condition. The aim of the present mini-review is to summarize the occurrence of epigenetic-based mechanisms in the context of PAH physiopathology, focusing on the roles of DNA methylation, histone post-translational modifications and non-coding RNAs. We also discuss the potential of epigenetic-based therapies for PAH. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x20187437 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.51 n.12 2018 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302946727690240 |