Epigenetic markers associated with schistosomiasis.

• Autor(a) principal: Assenço, Regina Aparecida Gomes
• Data de Publicação: 2021
• Outros Autores: Mota, Ester Alves, Oliveira, Victor Fernandes de, Borges, William de Castro, Cota, Renata Guerra de Sá
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/jspui/handle/123456789/14016; https://www.sciendo.com/article/10.2478/helm-2021-0009; https://doi.org/10.2478/helm-2021-0009
• topic: DNA methylation; Histone modification; miRNAs

It is important to consider the use of the epigenome as source of complementary data for genome knowledge, which is suitable for the diagnosis of schistosomiasis. Usually, a laboratory diagnosis of schistosomiasis is performed by means of 1. Egg detection in the stool or urine by microscopy remains with limited sensitivity; 2. Immunological screening, in which positivity persists after treatment, and 3. Molecular appraisals prevail over the disadvantages of the currently used methods. In this sense, molecular methodologies are being developed based on epigenetic biomarkers, aiming to improve the diagnosis of the disease and clinical treatment as early as possible to prevent the occurrence of serious liver damage.