Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500015 |
Resumo: | Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-depletion and partial extracellular fluid-repletion protocol which permits the distinction between sodium appetite and thirst. Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought. Water deprivation has physiological and health effects in humans that might be related to the salt craving shown by our species. |
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Brazilian Journal of Medical and Biological Research |
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Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetiteWater deprivationDehydrationMineral preferenceSodium appetiteCravingsWater deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-depletion and partial extracellular fluid-repletion protocol which permits the distinction between sodium appetite and thirst. Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought. Water deprivation has physiological and health effects in humans that might be related to the salt craving shown by our species.Associação Brasileira de Divulgação Científica2007-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500015Brazilian Journal of Medical and Biological Research v.40 n.5 2007reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2006005000101info:eu-repo/semantics/openAccessDe Luca,L.A. JrVendramini,R.C.Pereira,D.T.B.Colombari,D.A.S.David,R.B.Paula,P.M.Menani,J.V.eng2008-02-12T00:00:00Zoai:scielo:S0100-879X2007000500015Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2008-02-12T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite |
title |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite |
spellingShingle |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite De Luca,L.A. Jr Water deprivation Dehydration Mineral preference Sodium appetite Cravings |
title_short |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite |
title_full |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite |
title_fullStr |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite |
title_full_unstemmed |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite |
title_sort |
Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite |
author |
De Luca,L.A. Jr |
author_facet |
De Luca,L.A. Jr Vendramini,R.C. Pereira,D.T.B. Colombari,D.A.S. David,R.B. Paula,P.M. Menani,J.V. |
author_role |
author |
author2 |
Vendramini,R.C. Pereira,D.T.B. Colombari,D.A.S. David,R.B. Paula,P.M. Menani,J.V. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
De Luca,L.A. Jr Vendramini,R.C. Pereira,D.T.B. Colombari,D.A.S. David,R.B. Paula,P.M. Menani,J.V. |
dc.subject.por.fl_str_mv |
Water deprivation Dehydration Mineral preference Sodium appetite Cravings |
topic |
Water deprivation Dehydration Mineral preference Sodium appetite Cravings |
description |
Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-depletion and partial extracellular fluid-repletion protocol which permits the distinction between sodium appetite and thirst. Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought. Water deprivation has physiological and health effects in humans that might be related to the salt craving shown by our species. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2006005000101 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.40 n.5 2007 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302935922114560 |