Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite

Detalhes bibliográficos
Autor(a) principal: Pereira, E. D. [UNESP]
Data de Publicação: 2019
Outros Autores: Dantas, R. M. [UNESP], Andrade-Franzé, G. M.F. [UNESP], De Luca, L. A. [UNESP], Menani, J. V. [UNESP], Andrade, C. A.F. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.appet.2018.11.012
http://hdl.handle.net/11449/189927
Resumo: Excessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension and spontaneously hypertensive rats (SHR) have a typical increased sodium preference. Estrogens reduce sodium appetite, but we do not know whether such effect relates to alterations in sodium palatability. Here we evaluated the influence of ovarian hormones on orofacial motor responses, an index of palatability, to intra-oral infusion of 0.3 M NaCl (IO–NaCl). Adult female SHR and normotensive Holtzman rats (HTZ) were used. Sodium appetite was produced by water deprivation followed immediately by partial rehydration by drinking water to satiation (WD-PR protocol). Immediately at the end of WD-PR, animals received an IO-NaCl for videotape recording of orofacial motor responses. At the end of IO-NaCl, they had access to two bottles containing 0.3 M NaCl and water to ingest (sodium appetite test). Bilateral ovariectomy (OVX) enhanced 0.3 M NaCl intake during the sodium appetite test and increased the frequency of orofacial hedonic responses to IO-NaCl in both strains. It had no effect on aversive responses. Estradiol treatment in SHR-OVX decreased hedonic responses and increased aversive responses to IO-NaCl. It also reduced 0.3 M NaCl intake during the sodium appetite test, but had no effect on baseline mean arterial pressure and heart rate. The results suggest that ovarian hormones restrain WD-PR-induced sodium appetite by reducing the hedonic properties of sodium taste. The results also suggest that estrogens mediate such reduction, particularly in SHR.
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spelling Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetiteDehydrationHypertensionRewardSodium appetiteTasteWater deprivationExcessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension and spontaneously hypertensive rats (SHR) have a typical increased sodium preference. Estrogens reduce sodium appetite, but we do not know whether such effect relates to alterations in sodium palatability. Here we evaluated the influence of ovarian hormones on orofacial motor responses, an index of palatability, to intra-oral infusion of 0.3 M NaCl (IO–NaCl). Adult female SHR and normotensive Holtzman rats (HTZ) were used. Sodium appetite was produced by water deprivation followed immediately by partial rehydration by drinking water to satiation (WD-PR protocol). Immediately at the end of WD-PR, animals received an IO-NaCl for videotape recording of orofacial motor responses. At the end of IO-NaCl, they had access to two bottles containing 0.3 M NaCl and water to ingest (sodium appetite test). Bilateral ovariectomy (OVX) enhanced 0.3 M NaCl intake during the sodium appetite test and increased the frequency of orofacial hedonic responses to IO-NaCl in both strains. It had no effect on aversive responses. Estradiol treatment in SHR-OVX decreased hedonic responses and increased aversive responses to IO-NaCl. It also reduced 0.3 M NaCl intake during the sodium appetite test, but had no effect on baseline mean arterial pressure and heart rate. The results suggest that ovarian hormones restrain WD-PR-induced sodium appetite by reducing the hedonic properties of sodium taste. The results also suggest that estrogens mediate such reduction, particularly in SHR.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual PaulistaDepartment of Physiology and Pathology School of Dentistry UNESP – São Paulo State UniversityDepartment of Physiology and Pathology School of Dentistry UNESP – São Paulo State UniversityFAPESP: 2015/20500-3CNPq: 478960/2013-1Universidade Estadual Paulista (Unesp)Pereira, E. D. [UNESP]Dantas, R. M. [UNESP]Andrade-Franzé, G. M.F. [UNESP]De Luca, L. A. [UNESP]Menani, J. V. [UNESP]Andrade, C. A.F. [UNESP]2019-10-06T16:56:47Z2019-10-06T16:56:47Z2019-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article252-261http://dx.doi.org/10.1016/j.appet.2018.11.012Appetite, v. 133, p. 252-261.1095-83040195-6663http://hdl.handle.net/11449/18992710.1016/j.appet.2018.11.0122-s2.0-85057346916Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAppetiteinfo:eu-repo/semantics/openAccess2021-10-23T15:55:12Zoai:repositorio.unesp.br:11449/189927Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T15:55:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
title Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
spellingShingle Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
Pereira, E. D. [UNESP]
Dehydration
Hypertension
Reward
Sodium appetite
Taste
Water deprivation
title_short Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
title_full Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
title_fullStr Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
title_full_unstemmed Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
title_sort Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite
author Pereira, E. D. [UNESP]
author_facet Pereira, E. D. [UNESP]
Dantas, R. M. [UNESP]
Andrade-Franzé, G. M.F. [UNESP]
De Luca, L. A. [UNESP]
Menani, J. V. [UNESP]
Andrade, C. A.F. [UNESP]
author_role author
author2 Dantas, R. M. [UNESP]
Andrade-Franzé, G. M.F. [UNESP]
De Luca, L. A. [UNESP]
Menani, J. V. [UNESP]
Andrade, C. A.F. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Pereira, E. D. [UNESP]
Dantas, R. M. [UNESP]
Andrade-Franzé, G. M.F. [UNESP]
De Luca, L. A. [UNESP]
Menani, J. V. [UNESP]
Andrade, C. A.F. [UNESP]
dc.subject.por.fl_str_mv Dehydration
Hypertension
Reward
Sodium appetite
Taste
Water deprivation
topic Dehydration
Hypertension
Reward
Sodium appetite
Taste
Water deprivation
description Excessive salt intake has been associated with the development or worsening of chronic diseases such as hypertension and spontaneously hypertensive rats (SHR) have a typical increased sodium preference. Estrogens reduce sodium appetite, but we do not know whether such effect relates to alterations in sodium palatability. Here we evaluated the influence of ovarian hormones on orofacial motor responses, an index of palatability, to intra-oral infusion of 0.3 M NaCl (IO–NaCl). Adult female SHR and normotensive Holtzman rats (HTZ) were used. Sodium appetite was produced by water deprivation followed immediately by partial rehydration by drinking water to satiation (WD-PR protocol). Immediately at the end of WD-PR, animals received an IO-NaCl for videotape recording of orofacial motor responses. At the end of IO-NaCl, they had access to two bottles containing 0.3 M NaCl and water to ingest (sodium appetite test). Bilateral ovariectomy (OVX) enhanced 0.3 M NaCl intake during the sodium appetite test and increased the frequency of orofacial hedonic responses to IO-NaCl in both strains. It had no effect on aversive responses. Estradiol treatment in SHR-OVX decreased hedonic responses and increased aversive responses to IO-NaCl. It also reduced 0.3 M NaCl intake during the sodium appetite test, but had no effect on baseline mean arterial pressure and heart rate. The results suggest that ovarian hormones restrain WD-PR-induced sodium appetite by reducing the hedonic properties of sodium taste. The results also suggest that estrogens mediate such reduction, particularly in SHR.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:56:47Z
2019-10-06T16:56:47Z
2019-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.appet.2018.11.012
Appetite, v. 133, p. 252-261.
1095-8304
0195-6663
http://hdl.handle.net/11449/189927
10.1016/j.appet.2018.11.012
2-s2.0-85057346916
url http://dx.doi.org/10.1016/j.appet.2018.11.012
http://hdl.handle.net/11449/189927
identifier_str_mv Appetite, v. 133, p. 252-261.
1095-8304
0195-6663
10.1016/j.appet.2018.11.012
2-s2.0-85057346916
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Appetite
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 252-261
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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