Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

• Autor(a) principal: Garcia,V.P.
• Data de Publicação: 2022
• Outros Autores: Mattos,J.D., Mentzinger,J., Leite,P.E.C., Rocha,H.N.M., Campos,M.O., Rocha,M.P., Mansur,D.E., Secher,N.H., Nóbrega,A.C.L., Fernandes,I.A., Rocha,N.G.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Medical and Biological Research
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100637
• topic: Endothelium; Hyperoxia; ICAM-1; Metalloproteinase-9; Vascular remodeling

In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.