What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?

Detalhes bibliográficos
Autor(a) principal: Campos-Neto,A.
Data de Publicação: 2005
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001
Resumo: The T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.
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spelling What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?LeishmaniaTh1/Th2 paradigmInfectionVaccineAntigen discoveryAdjuvantThe T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.Associação Brasileira de Divulgação Científica2005-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001Brazilian Journal of Medical and Biological Research v.38 n.7 2005reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2005000700001info:eu-repo/semantics/openAccessCampos-Neto,A.eng2005-07-04T00:00:00Zoai:scielo:S0100-879X2005000700001Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2005-07-04T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
spellingShingle What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
Campos-Neto,A.
Leishmania
Th1/Th2 paradigm
Infection
Vaccine
Antigen discovery
Adjuvant
title_short What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_full What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_fullStr What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_full_unstemmed What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_sort What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
author Campos-Neto,A.
author_facet Campos-Neto,A.
author_role author
dc.contributor.author.fl_str_mv Campos-Neto,A.
dc.subject.por.fl_str_mv Leishmania
Th1/Th2 paradigm
Infection
Vaccine
Antigen discovery
Adjuvant
topic Leishmania
Th1/Th2 paradigm
Infection
Vaccine
Antigen discovery
Adjuvant
description The T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.
publishDate 2005
dc.date.none.fl_str_mv 2005-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2005000700001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.38 n.7 2005
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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