Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5803 |
Resumo: | Trabalho completo: acesso restrito, p.3333–3340 |
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Santos, Joelma Trigo dosAbbehusen, Melissa Moura CostaMartins Netto, EduardoNakatani, MariaSampaio, Geraldo PedralJesus, Robson Silva deGoto, YasuyukiGuderian, JeffreyHoward, Randall F.Reed, Steven G.Santos, Joelma Trigo dosAbbehusen, Melissa Moura CostaMartins Netto, EduardoNakatani, MariaSampaio, Geraldo PedralJesus, Robson Silva deGoto, YasuyukiGuderian, JeffreyHoward, Randall F.Reed, Steven G.2012-05-09T16:20:44Z2010-04-2610.1016/j.vaccine.2010.02.089http://www.repositorio.ufba.br/ri/handle/ri/5803v. 28, n. 19Trabalho completo: acesso restrito, p.3333–3340Immunotherapy of canine visceral leishmaniasis (CVL) may provide an alternative to both marginally effective chemotherapy and undesired euthanasia of infected dogs and could have a great impact not only on animal welfare, but also on control of human disease. Therefore, we examined the potential immunotherapeutic efficacy of the subunit vaccine Leish-111f + MPL-SE, which has undergone rigorous preclinical testing and been demonstrated safe in human clinical trials. Two separate trials were performed in Salvador, Brazil, to evaluate the vaccine for therapeutic efficacy against CVL caused by natural infection: an Open Trial and a Blinded Trial. In the Open Trial 59 dogs with clinically active CVL were sequentially allocated to four groups: group 1 received Leish-111f + MPL-SE; group 2 was treated with Glucantime; group 3 received a combination of the vaccine and Glucantime; and group 4 was given no treatment. At the 6-month assessment, the 13 non-treated dogs had either died or showed no clinical improvement. In contrast, most dogs in groups 1–3 showed initial improvement (100%, 80%, and 92%, respectively). Upon evaluation for a mean of 36 months after therapy, the following cure rates were observed: 75% for group 1 dogs (exact 95% confidence interval [CI] 43–95%), 64% for group 2 dogs (exact 95% CI 31–89%), and 50% for group 3 dogs (exact 95% CI 19–81%). Therapeutic efficacy of the Leish-111f + MPL-SE vaccine was reconfirmed in a subsequent Blinded Trial. The vaccine was effective for mild cases of CVL and was compromised in dogs with severe disease. Although further studies are required to understand mechanisms of action, the Leish-111f + MPL-SE vaccine is a promising tool to control VL in both dogs and humans.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-05-09T16:20:44Z No. of bitstreams: 1 4.pdf: 444282 bytes, checksum: 323a2175051395e734ff70b3b7a8ff84 (MD5)Made available in DSpace on 2012-05-09T16:20:44Z (GMT). No. of bitstreams: 1 4.pdf: 444282 bytes, checksum: 323a2175051395e734ff70b3b7a8ff84 (MD5) Previous issue date: 2010-04-26SalvadorElsevierhttp://dx.doi.org/10.1016/j.vaccine.2010.02.089reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAVisceral leishmaniasisLeishmania infantumDogImmunotherapyVaccineAdjuvantTreatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SEVaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL4.pdf4.pdfapplication/pdf444282https://repositorio.ufba.br/bitstream/ri/5803/1/4.pdf323a2175051395e734ff70b3b7a8ff84MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5803/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT4.pdf.txt4.pdf.txtExtracted texttext/plain48591https://repositorio.ufba.br/bitstream/ri/5803/3/4.pdf.txt80522f77ba6711591f71977230ac236cMD53ri/58032022-07-05 14:03:00.141oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE |
| dc.title.alternative.pt_BR.fl_str_mv |
Vaccine |
| title |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE |
| spellingShingle |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE Santos, Joelma Trigo dos Visceral leishmaniasis Leishmania infantum Dog Immunotherapy Vaccine Adjuvant |
| title_short |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE |
| title_full |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE |
| title_fullStr |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE |
| title_full_unstemmed |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE |
| title_sort |
Treatment of canine visceral leishmaniasis by the vaccine Leish-111f + MPL-SE |
| author |
Santos, Joelma Trigo dos |
| author_facet |
Santos, Joelma Trigo dos Abbehusen, Melissa Moura Costa Martins Netto, Eduardo Nakatani, Maria Sampaio, Geraldo Pedral Jesus, Robson Silva de Goto, Yasuyuki Guderian, Jeffrey Howard, Randall F. Reed, Steven G. |
| author_role |
author |
| author2 |
Abbehusen, Melissa Moura Costa Martins Netto, Eduardo Nakatani, Maria Sampaio, Geraldo Pedral Jesus, Robson Silva de Goto, Yasuyuki Guderian, Jeffrey Howard, Randall F. Reed, Steven G. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Joelma Trigo dos Abbehusen, Melissa Moura Costa Martins Netto, Eduardo Nakatani, Maria Sampaio, Geraldo Pedral Jesus, Robson Silva de Goto, Yasuyuki Guderian, Jeffrey Howard, Randall F. Reed, Steven G. Santos, Joelma Trigo dos Abbehusen, Melissa Moura Costa Martins Netto, Eduardo Nakatani, Maria Sampaio, Geraldo Pedral Jesus, Robson Silva de Goto, Yasuyuki Guderian, Jeffrey Howard, Randall F. Reed, Steven G. |
| dc.subject.por.fl_str_mv |
Visceral leishmaniasis Leishmania infantum Dog Immunotherapy Vaccine Adjuvant |
| topic |
Visceral leishmaniasis Leishmania infantum Dog Immunotherapy Vaccine Adjuvant |
| description |
Trabalho completo: acesso restrito, p.3333–3340 |
| publishDate |
2010 |
| dc.date.issued.fl_str_mv |
2010-04-26 |
| dc.date.accessioned.fl_str_mv |
2012-05-09T16:20:44Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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10.1016/j.vaccine.2010.02.089 http://www.repositorio.ufba.br/ri/handle/ri/5803 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 28, n. 19 |
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10.1016/j.vaccine.2010.02.089 v. 28, n. 19 |
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http://www.repositorio.ufba.br/ri/handle/ri/5803 |
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eng |
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openAccess |
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Elsevier |
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Elsevier |
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http://dx.doi.org/10.1016/j.vaccine.2010.02.089 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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