Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders

Detalhes bibliográficos
Autor(a) principal: Li,Jin-bo
Data de Publicação: 2018
Outros Autores: Zhang,Rui, Han,Xiao, Piao,Chun-li
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400610
Resumo: Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in vivo and increased plasma membrane translocation of GLUT4 in C2C12 skeletal muscle cells. In conclusion, our observations suggested that ginsenoside Rg1 inhibited dietary-induced obesity and improved obesity-related insulin resistance and glucose intolerance by activation of the AMPK pathway.
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spelling Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disordersDiabetesGinsenoside Rg1Insulin resistanceBody weightObesityObesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in vivo and increased plasma membrane translocation of GLUT4 in C2C12 skeletal muscle cells. In conclusion, our observations suggested that ginsenoside Rg1 inhibited dietary-induced obesity and improved obesity-related insulin resistance and glucose intolerance by activation of the AMPK pathway.Associação Brasileira de Divulgação Científica2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400610Brazilian Journal of Medical and Biological Research v.51 n.4 2018reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20177139info:eu-repo/semantics/openAccessLi,Jin-boZhang,RuiHan,XiaoPiao,Chun-lieng2019-03-19T00:00:00Zoai:scielo:S0100-879X2018000400610Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
title Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
spellingShingle Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
Li,Jin-bo
Diabetes
Ginsenoside Rg1
Insulin resistance
Body weight
Obesity
title_short Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
title_full Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
title_fullStr Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
title_full_unstemmed Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
title_sort Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
author Li,Jin-bo
author_facet Li,Jin-bo
Zhang,Rui
Han,Xiao
Piao,Chun-li
author_role author
author2 Zhang,Rui
Han,Xiao
Piao,Chun-li
author2_role author
author
author
dc.contributor.author.fl_str_mv Li,Jin-bo
Zhang,Rui
Han,Xiao
Piao,Chun-li
dc.subject.por.fl_str_mv Diabetes
Ginsenoside Rg1
Insulin resistance
Body weight
Obesity
topic Diabetes
Ginsenoside Rg1
Insulin resistance
Body weight
Obesity
description Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in vivo and increased plasma membrane translocation of GLUT4 in C2C12 skeletal muscle cells. In conclusion, our observations suggested that ginsenoside Rg1 inhibited dietary-induced obesity and improved obesity-related insulin resistance and glucose intolerance by activation of the AMPK pathway.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400610
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000400610
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x20177139
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.51 n.4 2018
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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