Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH

Detalhes bibliográficos
Autor(a) principal: Armelin,H.A.
Data de Publicação: 1999
Outros Autores: Lotfi,C.F.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700007
Resumo: FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.
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spelling Control of the adrenocortical cell cycle: interaction between FGF2 and ACTHadrenocortical cell cycleACTHFGF2ERK-MAPKc-fos proto-oncogeneFGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.Associação Brasileira de Divulgação Científica1999-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700007Brazilian Journal of Medical and Biological Research v.32 n.7 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000700007info:eu-repo/semantics/openAccessArmelin,H.A.Lotfi,C.F.P.eng1999-06-25T00:00:00Zoai:scielo:S0100-879X1999000700007Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-06-25T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
title Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
spellingShingle Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
Armelin,H.A.
adrenocortical cell cycle
ACTH
FGF2
ERK-MAPK
c-fos proto-oncogene
title_short Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
title_full Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
title_fullStr Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
title_full_unstemmed Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
title_sort Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
author Armelin,H.A.
author_facet Armelin,H.A.
Lotfi,C.F.P.
author_role author
author2 Lotfi,C.F.P.
author2_role author
dc.contributor.author.fl_str_mv Armelin,H.A.
Lotfi,C.F.P.
dc.subject.por.fl_str_mv adrenocortical cell cycle
ACTH
FGF2
ERK-MAPK
c-fos proto-oncogene
topic adrenocortical cell cycle
ACTH
FGF2
ERK-MAPK
c-fos proto-oncogene
description FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.
publishDate 1999
dc.date.none.fl_str_mv 1999-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X1999000700007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.32 n.7 1999
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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