The hematopoietic stroma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1999 |
| Outros Autores: | |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Brazilian Journal of Medical and Biological Research |
| Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500014 |
Resumo: | All blood cells are derived from a small common pool of totipotent cells, called hematopoietic stem cells. The process is strictly regulated by the hematopoietic microenvironment, which includes stromal cells, extracellular matrix molecules and soluble regulatory factors. Several experimental in vitro assays have been developed for the study of hematopoietic differentiation, and have provided valuable information on the stroma, which includes, among other cell types, macrophages, fibroblasts, adipocytes, and endothelial cells. The composition, ontogeny, and function in physiological as well as pathological conditions of stroma are discussed. |
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The hematopoietic stromahematopoiesismicroenvironmentstromaAll blood cells are derived from a small common pool of totipotent cells, called hematopoietic stem cells. The process is strictly regulated by the hematopoietic microenvironment, which includes stromal cells, extracellular matrix molecules and soluble regulatory factors. Several experimental in vitro assays have been developed for the study of hematopoietic differentiation, and have provided valuable information on the stroma, which includes, among other cell types, macrophages, fibroblasts, adipocytes, and endothelial cells. The composition, ontogeny, and function in physiological as well as pathological conditions of stroma are discussed.Associação Brasileira de Divulgação Científica1999-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500014Brazilian Journal of Medical and Biological Research v.32 n.5 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000500014info:eu-repo/semantics/openAccessNardi,N.B.Alfonso,Z.Z.C.eng1999-04-27T00:00:00Zoai:scielo:S0100-879X1999000500014Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-04-27T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
| dc.title.none.fl_str_mv |
The hematopoietic stroma |
| title |
The hematopoietic stroma |
| spellingShingle |
The hematopoietic stroma Nardi,N.B. hematopoiesis microenvironment stroma |
| title_short |
The hematopoietic stroma |
| title_full |
The hematopoietic stroma |
| title_fullStr |
The hematopoietic stroma |
| title_full_unstemmed |
The hematopoietic stroma |
| title_sort |
The hematopoietic stroma |
| author |
Nardi,N.B. |
| author_facet |
Nardi,N.B. Alfonso,Z.Z.C. |
| author_role |
author |
| author2 |
Alfonso,Z.Z.C. |
| author2_role |
author |
| dc.contributor.author.fl_str_mv |
Nardi,N.B. Alfonso,Z.Z.C. |
| dc.subject.por.fl_str_mv |
hematopoiesis microenvironment stroma |
| topic |
hematopoiesis microenvironment stroma |
| description |
All blood cells are derived from a small common pool of totipotent cells, called hematopoietic stem cells. The process is strictly regulated by the hematopoietic microenvironment, which includes stromal cells, extracellular matrix molecules and soluble regulatory factors. Several experimental in vitro assays have been developed for the study of hematopoietic differentiation, and have provided valuable information on the stroma, which includes, among other cell types, macrophages, fibroblasts, adipocytes, and endothelial cells. The composition, ontogeny, and function in physiological as well as pathological conditions of stroma are discussed. |
| publishDate |
1999 |
| dc.date.none.fl_str_mv |
1999-05-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500014 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500014 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1590/S0100-879X1999000500014 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
| publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
| dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.32 n.5 1999 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
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Associação Brasileira de Divulgação Científica (ABDC) |
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ABDC |
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ABDC |
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Brazilian Journal of Medical and Biological Research |
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Brazilian Journal of Medical and Biological Research |
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Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
| repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
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1754302929962008576 |