The Hematopoietic stroma

Detalhes bibliográficos
Autor(a) principal: Nardi, Nance Beyer
Data de Publicação: 1999
Outros Autores: Alfonso, Zeni Zoraia da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/21156
Resumo: All blood cells are derived from a small common pool of totipotent cells, called hematopoietic stem cells. The process is strictly regulated by the hematopoietic microenvironment, which includes stromal cells, extracellular matrix molecules and soluble regulatory factors. Several experimental in vitro assays have been developed for the study of hematopoietic differentiation, and have provided valuable information on the stroma, which includes, among other cell types, macrophages, fibroblasts, adipocytes, and endothelial cells. The composition, ontogeny, and function in physiological as well as pathological conditions of stroma are discussed.
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spelling Nardi, Nance BeyerAlfonso, Zeni Zoraia da Costa2010-04-24T04:15:31Z19990100-879Xhttp://hdl.handle.net/10183/21156000295680All blood cells are derived from a small common pool of totipotent cells, called hematopoietic stem cells. The process is strictly regulated by the hematopoietic microenvironment, which includes stromal cells, extracellular matrix molecules and soluble regulatory factors. Several experimental in vitro assays have been developed for the study of hematopoietic differentiation, and have provided valuable information on the stroma, which includes, among other cell types, macrophages, fibroblasts, adipocytes, and endothelial cells. The composition, ontogeny, and function in physiological as well as pathological conditions of stroma are discussed.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 32, no. 5 (May 1999), p. 601-609.GenéticaHematopoiesisMicroenvironmentStromaThe Hematopoietic stromainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000295680.pdf000295680.pdfTexto completo (inglês)application/pdf113531http://www.lume.ufrgs.br/bitstream/10183/21156/1/000295680.pdfa84e1a8783c09d1faf0075b9cf364acaMD51TEXT000295680.pdf.txt000295680.pdf.txtExtracted Texttext/plain39042http://www.lume.ufrgs.br/bitstream/10183/21156/2/000295680.pdf.txt533a60aa5d735eb3a6f1e2bc48dbf05fMD52THUMBNAIL000295680.pdf.jpg000295680.pdf.jpgGenerated Thumbnailimage/jpeg1720http://www.lume.ufrgs.br/bitstream/10183/21156/3/000295680.pdf.jpg19b9d89d203cb66928267866e5e68a47MD5310183/211562018-10-08 09:23:12.711oai:www.lume.ufrgs.br:10183/21156Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-08T12:23:12Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv The Hematopoietic stroma
title The Hematopoietic stroma
spellingShingle The Hematopoietic stroma
Nardi, Nance Beyer
Genética
Hematopoiesis
Microenvironment
Stroma
title_short The Hematopoietic stroma
title_full The Hematopoietic stroma
title_fullStr The Hematopoietic stroma
title_full_unstemmed The Hematopoietic stroma
title_sort The Hematopoietic stroma
author Nardi, Nance Beyer
author_facet Nardi, Nance Beyer
Alfonso, Zeni Zoraia da Costa
author_role author
author2 Alfonso, Zeni Zoraia da Costa
author2_role author
dc.contributor.author.fl_str_mv Nardi, Nance Beyer
Alfonso, Zeni Zoraia da Costa
dc.subject.por.fl_str_mv Genética
topic Genética
Hematopoiesis
Microenvironment
Stroma
dc.subject.eng.fl_str_mv Hematopoiesis
Microenvironment
Stroma
description All blood cells are derived from a small common pool of totipotent cells, called hematopoietic stem cells. The process is strictly regulated by the hematopoietic microenvironment, which includes stromal cells, extracellular matrix molecules and soluble regulatory factors. Several experimental in vitro assays have been developed for the study of hematopoietic differentiation, and have provided valuable information on the stroma, which includes, among other cell types, macrophages, fibroblasts, adipocytes, and endothelial cells. The composition, ontogeny, and function in physiological as well as pathological conditions of stroma are discussed.
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dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 32, no. 5 (May 1999), p. 601-609.
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