The role of necroptosis in neurosurgical diseases

Detalhes bibliográficos
Autor(a) principal: Liu,T.
Data de Publicação: 2015
Outros Autores: Bao,Y.H., Wang,Y., Jiang,J.Y.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400292
Resumo: Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
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spelling The role of necroptosis in neurosurgical diseasesMolecular mechanismPathogenesisProgrammed cell deathTherapyProgrammed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.Associação Brasileira de Divulgação Científica2015-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400292Brazilian Journal of Medical and Biological Research v.48 n.4 2015reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20144310info:eu-repo/semantics/openAccessLiu,T.Bao,Y.H.Wang,Y.Jiang,J.Y.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2015000400292Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv The role of necroptosis in neurosurgical diseases
title The role of necroptosis in neurosurgical diseases
spellingShingle The role of necroptosis in neurosurgical diseases
Liu,T.
Molecular mechanism
Pathogenesis
Programmed cell death
Therapy
title_short The role of necroptosis in neurosurgical diseases
title_full The role of necroptosis in neurosurgical diseases
title_fullStr The role of necroptosis in neurosurgical diseases
title_full_unstemmed The role of necroptosis in neurosurgical diseases
title_sort The role of necroptosis in neurosurgical diseases
author Liu,T.
author_facet Liu,T.
Bao,Y.H.
Wang,Y.
Jiang,J.Y.
author_role author
author2 Bao,Y.H.
Wang,Y.
Jiang,J.Y.
author2_role author
author
author
dc.contributor.author.fl_str_mv Liu,T.
Bao,Y.H.
Wang,Y.
Jiang,J.Y.
dc.subject.por.fl_str_mv Molecular mechanism
Pathogenesis
Programmed cell death
Therapy
topic Molecular mechanism
Pathogenesis
Programmed cell death
Therapy
description Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400292
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400292
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x20144310
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.48 n.4 2015
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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