A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine

Detalhes bibliográficos
Autor(a) principal: Gimenes,G.M.
Data de Publicação: 2022
Outros Autores: Santana,G.O., Scervino,M.V.M., Curi,R., Pereira,J.N.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306
Resumo: The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state.
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spelling A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestineGastrointestinal tractType 2 diabetesGK ratsIntestinal microbiotaDiabetes treatmentThe Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state.Associação Brasileira de Divulgação Científica2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306Brazilian Journal of Medical and Biological Research v.55 2022reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x2022e11910info:eu-repo/semantics/openAccessGimenes,G.M.Santana,G.O.Scervino,M.V.M.Curi,R.Pereira,J.N.B.eng2022-08-18T00:00:00Zoai:scielo:S0100-879X2022000100306Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2022-08-18T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
title A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
spellingShingle A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
Gimenes,G.M.
Gastrointestinal tract
Type 2 diabetes
GK rats
Intestinal microbiota
Diabetes treatment
title_short A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
title_full A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
title_fullStr A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
title_full_unstemmed A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
title_sort A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
author Gimenes,G.M.
author_facet Gimenes,G.M.
Santana,G.O.
Scervino,M.V.M.
Curi,R.
Pereira,J.N.B.
author_role author
author2 Santana,G.O.
Scervino,M.V.M.
Curi,R.
Pereira,J.N.B.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gimenes,G.M.
Santana,G.O.
Scervino,M.V.M.
Curi,R.
Pereira,J.N.B.
dc.subject.por.fl_str_mv Gastrointestinal tract
Type 2 diabetes
GK rats
Intestinal microbiota
Diabetes treatment
topic Gastrointestinal tract
Type 2 diabetes
GK rats
Intestinal microbiota
Diabetes treatment
description The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x2022e11910
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.55 2022
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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