Eosinophil-active chemokines: assessment of in vivo activity

• Autor(a) principal: Teixeira,M.M.
• Data de Publicação: 1998
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Medical and Biological Research
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100003
• topic: eosinophils; chemokines; eotaxin; MIP-1<FONT FACE=Symbol>a</font>; chemokine receptors

The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1<FONT FACE="Symbol">a</font> induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1<FONT FACE="Symbol">a</font>. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo