Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006 |
Resumo: | The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni. |
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Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansonieosinophilschemokine receptorschemokinesacute schistosomiasisThe recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.Instituto Oswaldo Cruz, Ministério da Saúde2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006Memórias do Instituto Oswaldo Cruz v.105 n.4 2010reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762010000400006info:eu-repo/semantics/openAccessSilveira-Lemos,DeniseTeixeira-Carvalho,AndréaMartins-Filho,Olindo AssisSouza-Soares,Adriano LuizCastro-Silva,PollyannaCosta-Silva,Matheus FernandesGuimarães,Pedro Henrique GazzinelliFerraz,Helena BarbosaOliveira-Fraga,Lúcia AlvesTeixeira,Mauro MartinsCorrêa-Oliveira,Rodrigoeng2020-04-25T17:50:47Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:57.872Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni |
title |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni |
spellingShingle |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni Silveira-Lemos,Denise eosinophils chemokine receptors chemokines acute schistosomiasis |
title_short |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni |
title_full |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni |
title_fullStr |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni |
title_full_unstemmed |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni |
title_sort |
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni |
author |
Silveira-Lemos,Denise |
author_facet |
Silveira-Lemos,Denise Teixeira-Carvalho,Andréa Martins-Filho,Olindo Assis Souza-Soares,Adriano Luiz Castro-Silva,Pollyanna Costa-Silva,Matheus Fernandes Guimarães,Pedro Henrique Gazzinelli Ferraz,Helena Barbosa Oliveira-Fraga,Lúcia Alves Teixeira,Mauro Martins Corrêa-Oliveira,Rodrigo |
author_role |
author |
author2 |
Teixeira-Carvalho,Andréa Martins-Filho,Olindo Assis Souza-Soares,Adriano Luiz Castro-Silva,Pollyanna Costa-Silva,Matheus Fernandes Guimarães,Pedro Henrique Gazzinelli Ferraz,Helena Barbosa Oliveira-Fraga,Lúcia Alves Teixeira,Mauro Martins Corrêa-Oliveira,Rodrigo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silveira-Lemos,Denise Teixeira-Carvalho,Andréa Martins-Filho,Olindo Assis Souza-Soares,Adriano Luiz Castro-Silva,Pollyanna Costa-Silva,Matheus Fernandes Guimarães,Pedro Henrique Gazzinelli Ferraz,Helena Barbosa Oliveira-Fraga,Lúcia Alves Teixeira,Mauro Martins Corrêa-Oliveira,Rodrigo |
dc.subject.por.fl_str_mv |
eosinophils chemokine receptors chemokines acute schistosomiasis |
topic |
eosinophils chemokine receptors chemokines acute schistosomiasis |
dc.description.none.fl_txt_mv |
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni. |
description |
The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762010000400006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.105 n.4 2010 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
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