Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal: Silveira-Lemos,Denise
Data de Publicação: 2010
Outros Autores: Teixeira-Carvalho,Andréa, Martins-Filho,Olindo Assis, Souza-Soares,Adriano Luiz, Castro-Silva,Pollyanna, Costa-Silva,Matheus Fernandes, Guimarães,Pedro Henrique Gazzinelli, Ferraz,Helena Barbosa, Oliveira-Fraga,Lúcia Alves, Teixeira,Mauro Martins, Corrêa-Oliveira,Rodrigo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006
Resumo: The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.
id FIOCRUZ-4_82ced77b4c1762c1f30a409eea742515
oai_identifier_str oai:scielo:S0074-02762010000400006
network_acronym_str FIOCRUZ-4
network_name_str Memórias do Instituto Oswaldo Cruz
spelling Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansonieosinophilschemokine receptorschemokinesacute schistosomiasisThe recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.Instituto Oswaldo Cruz, Ministério da Saúde2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006Memórias do Instituto Oswaldo Cruz v.105 n.4 2010reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762010000400006info:eu-repo/semantics/openAccessSilveira-Lemos,DeniseTeixeira-Carvalho,AndréaMartins-Filho,Olindo AssisSouza-Soares,Adriano LuizCastro-Silva,PollyannaCosta-Silva,Matheus FernandesGuimarães,Pedro Henrique GazzinelliFerraz,Helena BarbosaOliveira-Fraga,Lúcia AlvesTeixeira,Mauro MartinsCorrêa-Oliveira,Rodrigoeng2020-04-25T17:50:47Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:57.872Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
spellingShingle Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
Silveira-Lemos,Denise
eosinophils
chemokine receptors
chemokines
acute schistosomiasis
title_short Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_full Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_fullStr Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_full_unstemmed Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
title_sort Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
author Silveira-Lemos,Denise
author_facet Silveira-Lemos,Denise
Teixeira-Carvalho,Andréa
Martins-Filho,Olindo Assis
Souza-Soares,Adriano Luiz
Castro-Silva,Pollyanna
Costa-Silva,Matheus Fernandes
Guimarães,Pedro Henrique Gazzinelli
Ferraz,Helena Barbosa
Oliveira-Fraga,Lúcia Alves
Teixeira,Mauro Martins
Corrêa-Oliveira,Rodrigo
author_role author
author2 Teixeira-Carvalho,Andréa
Martins-Filho,Olindo Assis
Souza-Soares,Adriano Luiz
Castro-Silva,Pollyanna
Costa-Silva,Matheus Fernandes
Guimarães,Pedro Henrique Gazzinelli
Ferraz,Helena Barbosa
Oliveira-Fraga,Lúcia Alves
Teixeira,Mauro Martins
Corrêa-Oliveira,Rodrigo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silveira-Lemos,Denise
Teixeira-Carvalho,Andréa
Martins-Filho,Olindo Assis
Souza-Soares,Adriano Luiz
Castro-Silva,Pollyanna
Costa-Silva,Matheus Fernandes
Guimarães,Pedro Henrique Gazzinelli
Ferraz,Helena Barbosa
Oliveira-Fraga,Lúcia Alves
Teixeira,Mauro Martins
Corrêa-Oliveira,Rodrigo
dc.subject.por.fl_str_mv eosinophils
chemokine receptors
chemokines
acute schistosomiasis
topic eosinophils
chemokine receptors
chemokines
acute schistosomiasis
dc.description.none.fl_txt_mv The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.
description The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000400006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762010000400006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.105 n.4 2010
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937707887886336