Hepatic capillariasis in rats: a new model for testing antifibrotic drugs
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100011 |
Resumo: | Rats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered prophylactically (before fibrosis had started), but showed a poor effect when fibrosis was well advanced. No modification of fibrosis was seen after vitamin A administration. Hydroxyproline content was correlated with morphometric measurements. The model appears to be adequate, since few animals die of the infection, fibrosis develops regularly in all animals, and the effects of different antifibrotic drugs and administration protocols can be easily detected. |
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Brazilian Journal of Medical and Biological Research |
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Hepatic capillariasis in rats: a new model for testing antifibrotic drugsCapillaria hepaticahepatic fibrosisseptal fibrosisantifibrotic drugsRats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered prophylactically (before fibrosis had started), but showed a poor effect when fibrosis was well advanced. No modification of fibrosis was seen after vitamin A administration. Hydroxyproline content was correlated with morphometric measurements. The model appears to be adequate, since few animals die of the infection, fibrosis develops regularly in all animals, and the effects of different antifibrotic drugs and administration protocols can be easily detected.Associação Brasileira de Divulgação Científica2000-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100011Brazilian Journal of Medical and Biological Research v.33 n.11 2000reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2000001100011info:eu-repo/semantics/openAccessSouza,M.M. deSilva,L.M.Barbosa Jr.,A.A.de Oliveira,I.R.Paraná,R.Andrade,Z.A.eng2000-10-20T00:00:00Zoai:scielo:S0100-879X2000001100011Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2000-10-20T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs |
title |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs |
spellingShingle |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs Souza,M.M. de Capillaria hepatica hepatic fibrosis septal fibrosis antifibrotic drugs |
title_short |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs |
title_full |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs |
title_fullStr |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs |
title_full_unstemmed |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs |
title_sort |
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs |
author |
Souza,M.M. de |
author_facet |
Souza,M.M. de Silva,L.M. Barbosa Jr.,A.A. de Oliveira,I.R. Paraná,R. Andrade,Z.A. |
author_role |
author |
author2 |
Silva,L.M. Barbosa Jr.,A.A. de Oliveira,I.R. Paraná,R. Andrade,Z.A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Souza,M.M. de Silva,L.M. Barbosa Jr.,A.A. de Oliveira,I.R. Paraná,R. Andrade,Z.A. |
dc.subject.por.fl_str_mv |
Capillaria hepatica hepatic fibrosis septal fibrosis antifibrotic drugs |
topic |
Capillaria hepatica hepatic fibrosis septal fibrosis antifibrotic drugs |
description |
Rats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered prophylactically (before fibrosis had started), but showed a poor effect when fibrosis was well advanced. No modification of fibrosis was seen after vitamin A administration. Hydroxyproline content was correlated with morphometric measurements. The model appears to be adequate, since few animals die of the infection, fibrosis develops regularly in all animals, and the effects of different antifibrotic drugs and administration protocols can be easily detected. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2000001100011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.33 n.11 2000 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
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1754302930843860992 |