Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.

Detalhes bibliográficos
Autor(a) principal: Souza, Márcia Maria de
Data de Publicação: 2000
Outros Autores: Silva, L. M, Barbosa Junior, Aryon de Almeida, Oliveira, Irismar Reis de, Paraná, Raymundo, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5629
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Souza, Márcia Maria deSilva, L. MBarbosa Junior, Aryon de AlmeidaOliveira, Irismar Reis deParaná, RaymundoAndrade, Zilton de Araújo2012-10-03T17:44:46Z2012-10-03T17:44:46Z2000SOUZA, M.M. de et al. Hepatic capillariasis in rats: a new model for testing antifibrotic drugs. Brazilian Journal of Medical Biological Research, v. 33, n. 11, p. 1329-34, nov. 2000.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/5629engHepatic capillariasis in rats: a new model for testing antifibrotic drugs.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilRats infected with the helminth Capillaria hepatica regularly develop septal hepatic fibrosis that may progress to cirrhosis in a relatively short time. Because of such characteristics, this experimental model was selected for testing drugs exhibiting antifibrosis potential, such as pentoxifylline, gadolinium chloride and vitamin A. Hepatic fibrosis was qualitatively and quantitatively evaluated in liver samples obtained by partial hepatectomy and at autopsy. The material was submitted to histological, biochemical and morphometric methods. A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. Gadolinium chloride showed moderate activity when administered prophylactically (before fibrosis had started), but showed a poor effect when fibrosis was well advanced. No modification of fibrosis was seen after vitamin A administration. Hydroxyproline content was correlated with morphometric measurements. The model appears to be adequate, since few animals die of the infection, fibrosis develops regularly in all animals, and the effects of different antifibrotic drugs and administration protocols can be easily detected.Capillaria hepaticaHepatic fibrosisSeptal fibrosisAntifibrotic drugsInibidores da Agregação de Plaquetas/usoVitamina A/uso terapêuticoInfecções por Enoplida/quimioterapiaGadolínio/uso terapêuticoCirrose Hepática/quimioterapiaPentoxifilina/uso terapêuticoAnimaisCapillariaModelos Animais de DoençasFemininoCirrose Hepática/parasitologiaMasculinoRatosRatos WistarFatores de Tempoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5629/1/license.txt06db3f0df647fd9ddff657403bbe0ee2MD51ORIGINALde Souza MM Hepatic capillariasis in rats....pdfde Souza MM Hepatic capillariasis in rats....pdfapplication/pdf257330https://www.arca.fiocruz.br/bitstream/icict/5629/2/de%20Souza%20MM%20Hepatic%20capillariasis%20in%20rats....pdf4547a5c3e541aad0841ae2aed6449fd3MD52TEXTde Souza MM Hepatic capillariasis in rats....pdf.txtde Souza MM Hepatic capillariasis in rats....pdf.txtExtracted texttext/plain19229https://www.arca.fiocruz.br/bitstream/icict/5629/5/de%20Souza%20MM%20Hepatic%20capillariasis%20in%20rats....pdf.txt1136ac025613eb31609556af2e3ff2a2MD55THUMBNAILde Souza MM Hepatic capillariasis in rats....pdf.jpgde Souza MM Hepatic capillariasis in rats....pdf.jpgGenerated Thumbnailimage/jpeg2017https://www.arca.fiocruz.br/bitstream/icict/5629/4/de%20Souza%20MM%20Hepatic%20capillariasis%20in%20rats....pdf.jpg31e076160919c02f53c90d94dcfc3b1fMD54icict/56292023-03-15 14:33:02.28oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
title Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
spellingShingle Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
Souza, Márcia Maria de
Capillaria hepatica
Hepatic fibrosis
Septal fibrosis
Antifibrotic drugs
Inibidores da Agregação de Plaquetas/uso
Vitamina A/uso terapêutico
Infecções por Enoplida/quimioterapia
Gadolínio/uso terapêutico
Cirrose Hepática/quimioterapia
Pentoxifilina/uso terapêutico
Animais
Capillaria
Modelos Animais de Doenças
Feminino
Cirrose Hepática/parasitologia
Masculino
Ratos
Ratos Wistar
Fatores de Tempo
title_short Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
title_full Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
title_fullStr Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
title_full_unstemmed Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
title_sort Hepatic capillariasis in rats: a new model for testing antifibrotic drugs.
author Souza, Márcia Maria de
author_facet Souza, Márcia Maria de
Silva, L. M
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Paraná, Raymundo
Andrade, Zilton de Araújo
author_role author
author2 Silva, L. M
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Paraná, Raymundo
Andrade, Zilton de Araújo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Márcia Maria de
Silva, L. M
Barbosa Junior, Aryon de Almeida
Oliveira, Irismar Reis de
Paraná, Raymundo
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Capillaria hepatica
Hepatic fibrosis
Septal fibrosis
Antifibrotic drugs
Inibidores da Agregação de Plaquetas/uso
Vitamina A/uso terapêutico
topic Capillaria hepatica
Hepatic fibrosis
Septal fibrosis
Antifibrotic drugs
Inibidores da Agregação de Plaquetas/uso
Vitamina A/uso terapêutico
Infecções por Enoplida/quimioterapia
Gadolínio/uso terapêutico
Cirrose Hepática/quimioterapia
Pentoxifilina/uso terapêutico
Animais
Capillaria
Modelos Animais de Doenças
Feminino
Cirrose Hepática/parasitologia
Masculino
Ratos
Ratos Wistar
Fatores de Tempo
dc.subject.decs.pt_BR.fl_str_mv Infecções por Enoplida/quimioterapia
Gadolínio/uso terapêutico
Cirrose Hepática/quimioterapia
Pentoxifilina/uso terapêutico
Animais
Capillaria
Modelos Animais de Doenças
Feminino
Cirrose Hepática/parasitologia
Masculino
Ratos
Ratos Wistar
Fatores de Tempo
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2012-10-03T17:44:46Z
dc.date.available.fl_str_mv 2012-10-03T17:44:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SOUZA, M.M. de et al. Hepatic capillariasis in rats: a new model for testing antifibrotic drugs. Brazilian Journal of Medical Biological Research, v. 33, n. 11, p. 1329-34, nov. 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5629
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv SOUZA, M.M. de et al. Hepatic capillariasis in rats: a new model for testing antifibrotic drugs. Brazilian Journal of Medical Biological Research, v. 33, n. 11, p. 1329-34, nov. 2000.
0100-879X
url https://www.arca.fiocruz.br/handle/icict/5629
dc.language.iso.fl_str_mv eng
language eng
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