Mechanisms of cell transformation induced by polyomavirus
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010 |
Resumo: | Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control. |
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Brazilian Journal of Medical and Biological Research |
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Mechanisms of cell transformation induced by polyomavirussignal transductionmalignant transformationpolyomavirus T antigenspolyomavirus-induced transcriptional controlPolyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control.Associação Brasileira de Divulgação Científica1999-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010Brazilian Journal of Medical and Biological Research v.32 n.7 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000700010info:eu-repo/semantics/openAccessOliveira,M.L.S.Brochado,S.M.Sogayar,M.C.eng1999-06-25T00:00:00Zoai:scielo:S0100-879X1999000700010Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-06-25T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Mechanisms of cell transformation induced by polyomavirus |
title |
Mechanisms of cell transformation induced by polyomavirus |
spellingShingle |
Mechanisms of cell transformation induced by polyomavirus Oliveira,M.L.S. signal transduction malignant transformation polyomavirus T antigens polyomavirus-induced transcriptional control |
title_short |
Mechanisms of cell transformation induced by polyomavirus |
title_full |
Mechanisms of cell transformation induced by polyomavirus |
title_fullStr |
Mechanisms of cell transformation induced by polyomavirus |
title_full_unstemmed |
Mechanisms of cell transformation induced by polyomavirus |
title_sort |
Mechanisms of cell transformation induced by polyomavirus |
author |
Oliveira,M.L.S. |
author_facet |
Oliveira,M.L.S. Brochado,S.M. Sogayar,M.C. |
author_role |
author |
author2 |
Brochado,S.M. Sogayar,M.C. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Oliveira,M.L.S. Brochado,S.M. Sogayar,M.C. |
dc.subject.por.fl_str_mv |
signal transduction malignant transformation polyomavirus T antigens polyomavirus-induced transcriptional control |
topic |
signal transduction malignant transformation polyomavirus T antigens polyomavirus-induced transcriptional control |
description |
Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1999000700010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.32 n.7 1999 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302930011291648 |