Mechanisms of cell transformation induced by polyomavirus

Detalhes bibliográficos
Autor(a) principal: Oliveira,M.L.S.
Data de Publicação: 1999
Outros Autores: Brochado,S.M., Sogayar,M.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010
Resumo: Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control.
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spelling Mechanisms of cell transformation induced by polyomavirussignal transductionmalignant transformationpolyomavirus T antigenspolyomavirus-induced transcriptional controlPolyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control.Associação Brasileira de Divulgação Científica1999-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010Brazilian Journal of Medical and Biological Research v.32 n.7 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000700010info:eu-repo/semantics/openAccessOliveira,M.L.S.Brochado,S.M.Sogayar,M.C.eng1999-06-25T00:00:00Zoai:scielo:S0100-879X1999000700010Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-06-25T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Mechanisms of cell transformation induced by polyomavirus
title Mechanisms of cell transformation induced by polyomavirus
spellingShingle Mechanisms of cell transformation induced by polyomavirus
Oliveira,M.L.S.
signal transduction
malignant transformation
polyomavirus T antigens
polyomavirus-induced transcriptional control
title_short Mechanisms of cell transformation induced by polyomavirus
title_full Mechanisms of cell transformation induced by polyomavirus
title_fullStr Mechanisms of cell transformation induced by polyomavirus
title_full_unstemmed Mechanisms of cell transformation induced by polyomavirus
title_sort Mechanisms of cell transformation induced by polyomavirus
author Oliveira,M.L.S.
author_facet Oliveira,M.L.S.
Brochado,S.M.
Sogayar,M.C.
author_role author
author2 Brochado,S.M.
Sogayar,M.C.
author2_role author
author
dc.contributor.author.fl_str_mv Oliveira,M.L.S.
Brochado,S.M.
Sogayar,M.C.
dc.subject.por.fl_str_mv signal transduction
malignant transformation
polyomavirus T antigens
polyomavirus-induced transcriptional control
topic signal transduction
malignant transformation
polyomavirus T antigens
polyomavirus-induced transcriptional control
description Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control.
publishDate 1999
dc.date.none.fl_str_mv 1999-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X1999000700010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.32 n.7 1999
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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