Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome

Detalhes bibliográficos
Autor(a) principal: Peres,P.
Data de Publicação: 2010
Outros Autores: Bernardelli,G.F., Mendes,C.C., Fischer,S.S.C.P.M., Servantes,D.M., Medeiros,W.M., Carvalho,A.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400011
Resumo: Marfan syndrome (MS) is a dominant autosomal disease caused by mutations in chromosome 15, the locus controlling fibrillin 1 synthesis, and may exhibit skeletal, ocular, cardiovascular, and other manifestations. Pulse wave velocity (PWV) is used to measure arterial elasticity and stiffness and is related to the elastic properties of the vascular wall. Since the practice of exercise is limited in MS patients, it was of interest to analyze the acute effect of submaximal exercise on aortic distensibility using PWV and other hemodynamic variables in patients with MS with either mild or no aortic dilatation. PWV and physiological variables were evaluated before and after submaximal exercise in 33 patients with MS and 18 controls. PWV was 8.51 ± 0.58 at rest and 9.10 ± 0.63 m/s at the end of exercise (P = 0.002) in the group with MS and 8.07 ± 0.35 and 8.98 ± 0.56 m/s in the control group, respectively (P = 0.004). Comparative group analysis regarding PWV at rest and at the end of exercise revealed no statistically significant differences. The same was true for the group that used β-blockers and the one that did not. The final heart rate was 10% higher in the control group than in the MS group (P = 0.01). Final systolic arterial pressure was higher in the control group (P = 0.02). PWV in MS patients with mild or no aortic dilatation did not differ from the control group after submaximal effort.
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spelling Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndromeExerciseAortic elasticityPulse wave velocityMarfan syndromeMarfan syndrome (MS) is a dominant autosomal disease caused by mutations in chromosome 15, the locus controlling fibrillin 1 synthesis, and may exhibit skeletal, ocular, cardiovascular, and other manifestations. Pulse wave velocity (PWV) is used to measure arterial elasticity and stiffness and is related to the elastic properties of the vascular wall. Since the practice of exercise is limited in MS patients, it was of interest to analyze the acute effect of submaximal exercise on aortic distensibility using PWV and other hemodynamic variables in patients with MS with either mild or no aortic dilatation. PWV and physiological variables were evaluated before and after submaximal exercise in 33 patients with MS and 18 controls. PWV was 8.51 ± 0.58 at rest and 9.10 ± 0.63 m/s at the end of exercise (P = 0.002) in the group with MS and 8.07 ± 0.35 and 8.98 ± 0.56 m/s in the control group, respectively (P = 0.004). Comparative group analysis regarding PWV at rest and at the end of exercise revealed no statistically significant differences. The same was true for the group that used β-blockers and the one that did not. The final heart rate was 10% higher in the control group than in the MS group (P = 0.01). Final systolic arterial pressure was higher in the control group (P = 0.02). PWV in MS patients with mild or no aortic dilatation did not differ from the control group after submaximal effort.Associação Brasileira de Divulgação Científica2010-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400011Brazilian Journal of Medical and Biological Research v.43 n.4 2010reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2010007500021info:eu-repo/semantics/openAccessPeres,P.Bernardelli,G.F.Mendes,C.C.Fischer,S.S.C.P.M.Servantes,D.M.Medeiros,W.M.Carvalho,A.C.eng2010-04-08T00:00:00Zoai:scielo:S0100-879X2010000400011Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2010-04-08T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
title Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
spellingShingle Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
Peres,P.
Exercise
Aortic elasticity
Pulse wave velocity
Marfan syndrome
title_short Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
title_full Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
title_fullStr Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
title_full_unstemmed Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
title_sort Immediate effects of submaximal effort on pulse wave velocity in patients with Marfan syndrome
author Peres,P.
author_facet Peres,P.
Bernardelli,G.F.
Mendes,C.C.
Fischer,S.S.C.P.M.
Servantes,D.M.
Medeiros,W.M.
Carvalho,A.C.
author_role author
author2 Bernardelli,G.F.
Mendes,C.C.
Fischer,S.S.C.P.M.
Servantes,D.M.
Medeiros,W.M.
Carvalho,A.C.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Peres,P.
Bernardelli,G.F.
Mendes,C.C.
Fischer,S.S.C.P.M.
Servantes,D.M.
Medeiros,W.M.
Carvalho,A.C.
dc.subject.por.fl_str_mv Exercise
Aortic elasticity
Pulse wave velocity
Marfan syndrome
topic Exercise
Aortic elasticity
Pulse wave velocity
Marfan syndrome
description Marfan syndrome (MS) is a dominant autosomal disease caused by mutations in chromosome 15, the locus controlling fibrillin 1 synthesis, and may exhibit skeletal, ocular, cardiovascular, and other manifestations. Pulse wave velocity (PWV) is used to measure arterial elasticity and stiffness and is related to the elastic properties of the vascular wall. Since the practice of exercise is limited in MS patients, it was of interest to analyze the acute effect of submaximal exercise on aortic distensibility using PWV and other hemodynamic variables in patients with MS with either mild or no aortic dilatation. PWV and physiological variables were evaluated before and after submaximal exercise in 33 patients with MS and 18 controls. PWV was 8.51 ± 0.58 at rest and 9.10 ± 0.63 m/s at the end of exercise (P = 0.002) in the group with MS and 8.07 ± 0.35 and 8.98 ± 0.56 m/s in the control group, respectively (P = 0.004). Comparative group analysis regarding PWV at rest and at the end of exercise revealed no statistically significant differences. The same was true for the group that used β-blockers and the one that did not. The final heart rate was 10% higher in the control group than in the MS group (P = 0.01). Final systolic arterial pressure was higher in the control group (P = 0.02). PWV in MS patients with mild or no aortic dilatation did not differ from the control group after submaximal effort.
publishDate 2010
dc.date.none.fl_str_mv 2010-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2010007500021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.43 n.4 2010
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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