Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines

Detalhes bibliográficos
Autor(a) principal: Weng,K.-G.
Data de Publicação: 2017
Outros Autores: Yuan,Y.-L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100603
Resumo: Series of novel coumarin derivatives [I (a–d) and II (a–d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.
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spelling Synthesis and evaluation of coumarin derivatives against human lung cancer cell linesCoumarinX-rayLung cancerSeries of novel coumarin derivatives [I (a–d) and II (a–d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.Associação Brasileira de Divulgação Científica2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100603Brazilian Journal of Medical and Biological Research v.50 n.11 2017reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20176455info:eu-repo/semantics/openAccessWeng,K.-G.Yuan,Y.-L.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2017001100603Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
title Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
spellingShingle Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
Weng,K.-G.
Coumarin
X-ray
Lung cancer
title_short Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
title_full Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
title_fullStr Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
title_full_unstemmed Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
title_sort Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines
author Weng,K.-G.
author_facet Weng,K.-G.
Yuan,Y.-L.
author_role author
author2 Yuan,Y.-L.
author2_role author
dc.contributor.author.fl_str_mv Weng,K.-G.
Yuan,Y.-L.
dc.subject.por.fl_str_mv Coumarin
X-ray
Lung cancer
topic Coumarin
X-ray
Lung cancer
description Series of novel coumarin derivatives [I (a–d) and II (a–d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100603
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100603
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x20176455
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.50 n.11 2017
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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