DNA encoding individual mycobacterial antigens protects mice against tuberculosis
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200012 |
Resumo: | Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal to that from live BCG vaccine in mice. A critical determinant of the outcome of immunization appears to be the degree to which antigen-specific cytotoxic T cells are generated by the immune response. Our most recent studies indicate that DNA vaccination is an effective way to establish long-lasting cytotoxic T cell memory and protection against tuberculosis. |
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Brazilian Journal of Medical and Biological Research |
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DNA encoding individual mycobacterial antigens protects mice against tuberculosistuberculosisDNA vaccinationcytokinesTh1/Th2Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal to that from live BCG vaccine in mice. A critical determinant of the outcome of immunization appears to be the degree to which antigen-specific cytotoxic T cells are generated by the immune response. Our most recent studies indicate that DNA vaccination is an effective way to establish long-lasting cytotoxic T cell memory and protection against tuberculosis.Associação Brasileira de Divulgação Científica1999-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200012Brazilian Journal of Medical and Biological Research v.32 n.2 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000200012info:eu-repo/semantics/openAccessSilva,C.L.Bonato,V.L.D.Lima,V.M.F.eng1999-02-04T00:00:00Zoai:scielo:S0100-879X1999000200012Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-02-04T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis |
title |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis |
spellingShingle |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis Silva,C.L. tuberculosis DNA vaccination cytokines Th1/Th2 |
title_short |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis |
title_full |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis |
title_fullStr |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis |
title_full_unstemmed |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis |
title_sort |
DNA encoding individual mycobacterial antigens protects mice against tuberculosis |
author |
Silva,C.L. |
author_facet |
Silva,C.L. Bonato,V.L.D. Lima,V.M.F. |
author_role |
author |
author2 |
Bonato,V.L.D. Lima,V.M.F. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silva,C.L. Bonato,V.L.D. Lima,V.M.F. |
dc.subject.por.fl_str_mv |
tuberculosis DNA vaccination cytokines Th1/Th2 |
topic |
tuberculosis DNA vaccination cytokines Th1/Th2 |
description |
Over the last few years, some of our experiments in which mycobacterial antigens were presented to the immune system as if they were viral antigens have had a significant impact on our understanding of protective immunity against tuberculosis. They have also markedly enhanced the prospects for new vaccines. We now know that individual mycobacterial protein antigens can confer protection equal to that from live BCG vaccine in mice. A critical determinant of the outcome of immunization appears to be the degree to which antigen-specific cytotoxic T cells are generated by the immune response. Our most recent studies indicate that DNA vaccination is an effective way to establish long-lasting cytotoxic T cell memory and protection against tuberculosis. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000200012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1999000200012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.32 n.2 1999 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302929670504448 |