Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study

Detalhes bibliográficos
Autor(a) principal: Carmo,R.A.
Data de Publicação: 2002
Outros Autores: Oliveira,G.C., Guimarães,M.D.C., Oliveira,M.S., Lima,A.A., Buzek,S.C., Corrêa-Oliveira,R., Rocha,M.O.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012
Resumo: We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia.
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spelling Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological studyHepatitis C virusHCV genotypesHemophiliaChronic liver diseaseTransfusionBrazilWe determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia.Associação Brasileira de Divulgação Científica2002-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012Brazilian Journal of Medical and Biological Research v.35 n.5 2002reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2002000500012info:eu-repo/semantics/openAccessCarmo,R.A.Oliveira,G.C.Guimarães,M.D.C.Oliveira,M.S.Lima,A.A.Buzek,S.C.Corrêa-Oliveira,R.Rocha,M.O.C.eng2002-05-06T00:00:00Zoai:scielo:S0100-879X2002000500012Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2002-05-06T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
title Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
spellingShingle Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
Carmo,R.A.
Hepatitis C virus
HCV genotypes
Hemophilia
Chronic liver disease
Transfusion
Brazil
title_short Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
title_full Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
title_fullStr Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
title_full_unstemmed Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
title_sort Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study
author Carmo,R.A.
author_facet Carmo,R.A.
Oliveira,G.C.
Guimarães,M.D.C.
Oliveira,M.S.
Lima,A.A.
Buzek,S.C.
Corrêa-Oliveira,R.
Rocha,M.O.C.
author_role author
author2 Oliveira,G.C.
Guimarães,M.D.C.
Oliveira,M.S.
Lima,A.A.
Buzek,S.C.
Corrêa-Oliveira,R.
Rocha,M.O.C.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carmo,R.A.
Oliveira,G.C.
Guimarães,M.D.C.
Oliveira,M.S.
Lima,A.A.
Buzek,S.C.
Corrêa-Oliveira,R.
Rocha,M.O.C.
dc.subject.por.fl_str_mv Hepatitis C virus
HCV genotypes
Hemophilia
Chronic liver disease
Transfusion
Brazil
topic Hepatitis C virus
HCV genotypes
Hemophilia
Chronic liver disease
Transfusion
Brazil
description We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine transaminase (ALT) levels. Plasma HCV RNA was detected by nested-RT-PCR in 116 patients (71.6%). RFLP analysis showed the following genotype distribution: HCV-1 in 98 hemophiliacs (84.5%), HCV-3 in ten (8.6%), HCV-4 in three (2.6%), HCV-2 in one (0.9%), and not typeable in four cases (3.4%). Univariate analysis indicated that older age (P = 0.017) and abnormal ALT levels (P = 0.010) were associated with HCV viremia, while the presence of inhibitor antibodies (P = 0.024) and HBsAg (P = 0.007) represented a protective factor against the presence of HCV RNA. These findings may contribute to a better understanding of the relationship between HCV infection and hemophilia.
publishDate 2002
dc.date.none.fl_str_mv 2002-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2002000500012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.35 n.5 2002
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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