Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

Detalhes bibliográficos
Autor(a) principal: Vasco,Carolina Ferreira
Data de Publicação: 2018
Outros Autores: Watanabe,Mirian, Fonseca,Cassiane Dezoti da, Vattimo,Maria de Fátima Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Enfermagem (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000401921
Resumo: ABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.
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spelling Sepsis-induced acute kidney injury: kidney protection effects by antioxidantsAcute Kidney InjurySepsisDiosminHesperidinOxidative StressABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.Associação Brasileira de Enfermagem2018-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000401921Revista Brasileira de Enfermagem v.71 n.4 2018reponame:Revista Brasileira de Enfermagem (Online)instname:Associação Brasileira de Enfermagem (ABEN)instacron:ABEN10.1590/0034-7167-2017-0469info:eu-repo/semantics/openAccessVasco,Carolina FerreiraWatanabe,MirianFonseca,Cassiane Dezoti daVattimo,Maria de Fátima Fernandeseng2018-08-24T00:00:00Zoai:scielo:S0034-71672018000401921Revistahttp://www.scielo.br/rebenhttps://old.scielo.br/oai/scielo-oai.phpreben@abennacional.org.br||telma.garcia@abennacional.org.br|| editorreben@abennacional.org.br1984-04460034-7167opendoar:2018-08-24T00:00Revista Brasileira de Enfermagem (Online) - Associação Brasileira de Enfermagem (ABEN)false
dc.title.none.fl_str_mv Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
title Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
spellingShingle Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
Vasco,Carolina Ferreira
Acute Kidney Injury
Sepsis
Diosmin
Hesperidin
Oxidative Stress
title_short Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
title_full Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
title_fullStr Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
title_full_unstemmed Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
title_sort Sepsis-induced acute kidney injury: kidney protection effects by antioxidants
author Vasco,Carolina Ferreira
author_facet Vasco,Carolina Ferreira
Watanabe,Mirian
Fonseca,Cassiane Dezoti da
Vattimo,Maria de Fátima Fernandes
author_role author
author2 Watanabe,Mirian
Fonseca,Cassiane Dezoti da
Vattimo,Maria de Fátima Fernandes
author2_role author
author
author
dc.contributor.author.fl_str_mv Vasco,Carolina Ferreira
Watanabe,Mirian
Fonseca,Cassiane Dezoti da
Vattimo,Maria de Fátima Fernandes
dc.subject.por.fl_str_mv Acute Kidney Injury
Sepsis
Diosmin
Hesperidin
Oxidative Stress
topic Acute Kidney Injury
Sepsis
Diosmin
Hesperidin
Oxidative Stress
description ABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.
publishDate 2018
dc.date.none.fl_str_mv 2018-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000401921
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000401921
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0034-7167-2017-0469
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Enfermagem
publisher.none.fl_str_mv Associação Brasileira de Enfermagem
dc.source.none.fl_str_mv Revista Brasileira de Enfermagem v.71 n.4 2018
reponame:Revista Brasileira de Enfermagem (Online)
instname:Associação Brasileira de Enfermagem (ABEN)
instacron:ABEN
instname_str Associação Brasileira de Enfermagem (ABEN)
instacron_str ABEN
institution ABEN
reponame_str Revista Brasileira de Enfermagem (Online)
collection Revista Brasileira de Enfermagem (Online)
repository.name.fl_str_mv Revista Brasileira de Enfermagem (Online) - Associação Brasileira de Enfermagem (ABEN)
repository.mail.fl_str_mv reben@abennacional.org.br||telma.garcia@abennacional.org.br|| editorreben@abennacional.org.br
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