Antioxidant protection of statins in acute kidney injury induced by sepsis

Detalhes bibliográficos
Autor(a) principal: Santos,Franciele do Nascimento
Data de Publicação: 2014
Outros Autores: Watanabe,Mirian, Vasco,Carolina Ferreira, Fonseca,Cassiane Dezoti da, Vattimo,Maria de Fatima Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Escola de Enfermagem da USP (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342014000500820
Resumo: Objective Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. Method Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation – CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated. Results The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality. Conclusion This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.
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spelling Antioxidant protection of statins in acute kidney injury induced by sepsisAntioxidantsAcute kidney injurySepsis Objective Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. Method Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation – CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated. Results The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality. Conclusion This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model. Universidade de São Paulo, Escola de Enfermagem2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342014000500820Revista da Escola de Enfermagem da USP v.48 n.5 2014reponame:Revista da Escola de Enfermagem da USP (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S0080-6234201400005000007info:eu-repo/semantics/openAccessSantos,Franciele do NascimentoWatanabe,MirianVasco,Carolina FerreiraFonseca,Cassiane Dezoti daVattimo,Maria de Fatima Fernandeseng2014-12-03T00:00:00Zoai:scielo:S0080-62342014000500820Revistahttp://www.scielo.br/reeuspPUBhttps://old.scielo.br/oai/scielo-oai.php||nursingscholar@usp.br1980-220X0080-6234opendoar:2014-12-03T00:00Revista da Escola de Enfermagem da USP (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Antioxidant protection of statins in acute kidney injury induced by sepsis
title Antioxidant protection of statins in acute kidney injury induced by sepsis
spellingShingle Antioxidant protection of statins in acute kidney injury induced by sepsis
Santos,Franciele do Nascimento
Antioxidants
Acute kidney injury
Sepsis
title_short Antioxidant protection of statins in acute kidney injury induced by sepsis
title_full Antioxidant protection of statins in acute kidney injury induced by sepsis
title_fullStr Antioxidant protection of statins in acute kidney injury induced by sepsis
title_full_unstemmed Antioxidant protection of statins in acute kidney injury induced by sepsis
title_sort Antioxidant protection of statins in acute kidney injury induced by sepsis
author Santos,Franciele do Nascimento
author_facet Santos,Franciele do Nascimento
Watanabe,Mirian
Vasco,Carolina Ferreira
Fonseca,Cassiane Dezoti da
Vattimo,Maria de Fatima Fernandes
author_role author
author2 Watanabe,Mirian
Vasco,Carolina Ferreira
Fonseca,Cassiane Dezoti da
Vattimo,Maria de Fatima Fernandes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos,Franciele do Nascimento
Watanabe,Mirian
Vasco,Carolina Ferreira
Fonseca,Cassiane Dezoti da
Vattimo,Maria de Fatima Fernandes
dc.subject.por.fl_str_mv Antioxidants
Acute kidney injury
Sepsis
topic Antioxidants
Acute kidney injury
Sepsis
description Objective Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. Method Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation – CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated. Results The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality. Conclusion This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342014000500820
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342014000500820
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0080-6234201400005000007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade de São Paulo, Escola de Enfermagem
publisher.none.fl_str_mv Universidade de São Paulo, Escola de Enfermagem
dc.source.none.fl_str_mv Revista da Escola de Enfermagem da USP v.48 n.5 2014
reponame:Revista da Escola de Enfermagem da USP (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista da Escola de Enfermagem da USP (Online)
collection Revista da Escola de Enfermagem da USP (Online)
repository.name.fl_str_mv Revista da Escola de Enfermagem da USP (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||nursingscholar@usp.br
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