Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Chemical Engineering |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322009000300016 |
Resumo: | An experimental and theoretical study is presented for the fractionation of L-Tryptophan (Trp) from L-phenylalanine (Phe) and L-tyrosine (Tyr). A Simulated-Moving Bed (SMB) with four-column system was tested, and the results are presented as effluent histories of the raffinate and extract ports. L-phenylalanine and L-tyrosine were recovered as major products in the raffinate, while L-Tryptophan was recovered at the extract. To simulate the L-Tryptophan separation, a general rate model was used to represent the mass transfer phenomena that occur in each individual column of the SMB, for each solute present in the multicomponent system. A hybrid method was used to solve the model. An analytic solution was used for the intra-particle concentration, and was correlated to the liquid bed concentration by Duhamel's theorem. The results from simulation are compared with the experimental data presented in this work. |
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Brazilian Journal of Chemical Engineering |
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Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studiesSimulated-Moving BedAmino AcidsTriptophanAn experimental and theoretical study is presented for the fractionation of L-Tryptophan (Trp) from L-phenylalanine (Phe) and L-tyrosine (Tyr). A Simulated-Moving Bed (SMB) with four-column system was tested, and the results are presented as effluent histories of the raffinate and extract ports. L-phenylalanine and L-tyrosine were recovered as major products in the raffinate, while L-Tryptophan was recovered at the extract. To simulate the L-Tryptophan separation, a general rate model was used to represent the mass transfer phenomena that occur in each individual column of the SMB, for each solute present in the multicomponent system. A hybrid method was used to solve the model. An analytic solution was used for the intra-particle concentration, and was correlated to the liquid bed concentration by Duhamel's theorem. The results from simulation are compared with the experimental data presented in this work.Brazilian Society of Chemical Engineering2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322009000300016Brazilian Journal of Chemical Engineering v.26 n.3 2009reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/S0104-66322009000300016info:eu-repo/semantics/openAccessCremasco,M. A.Starquit,A.Wang,N.-H. L.eng2009-09-01T00:00:00Zoai:scielo:S0104-66322009000300016Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:2009-09-01T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false |
dc.title.none.fl_str_mv |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies |
title |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies |
spellingShingle |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies Cremasco,M. A. Simulated-Moving Bed Amino Acids Triptophan |
title_short |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies |
title_full |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies |
title_fullStr |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies |
title_full_unstemmed |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies |
title_sort |
Separation of l-tryptophan present in an aromatic amino acids mixture in a four-column simulated moving bed: experimental and simulation studies |
author |
Cremasco,M. A. |
author_facet |
Cremasco,M. A. Starquit,A. Wang,N.-H. L. |
author_role |
author |
author2 |
Starquit,A. Wang,N.-H. L. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Cremasco,M. A. Starquit,A. Wang,N.-H. L. |
dc.subject.por.fl_str_mv |
Simulated-Moving Bed Amino Acids Triptophan |
topic |
Simulated-Moving Bed Amino Acids Triptophan |
description |
An experimental and theoretical study is presented for the fractionation of L-Tryptophan (Trp) from L-phenylalanine (Phe) and L-tyrosine (Tyr). A Simulated-Moving Bed (SMB) with four-column system was tested, and the results are presented as effluent histories of the raffinate and extract ports. L-phenylalanine and L-tyrosine were recovered as major products in the raffinate, while L-Tryptophan was recovered at the extract. To simulate the L-Tryptophan separation, a general rate model was used to represent the mass transfer phenomena that occur in each individual column of the SMB, for each solute present in the multicomponent system. A hybrid method was used to solve the model. An analytic solution was used for the intra-particle concentration, and was correlated to the liquid bed concentration by Duhamel's theorem. The results from simulation are compared with the experimental data presented in this work. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322009000300016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322009000300016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0104-66322009000300016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
dc.source.none.fl_str_mv |
Brazilian Journal of Chemical Engineering v.26 n.3 2009 reponame:Brazilian Journal of Chemical Engineering instname:Associação Brasileira de Engenharia Química (ABEQ) instacron:ABEQ |
instname_str |
Associação Brasileira de Engenharia Química (ABEQ) |
instacron_str |
ABEQ |
institution |
ABEQ |
reponame_str |
Brazilian Journal of Chemical Engineering |
collection |
Brazilian Journal of Chemical Engineering |
repository.name.fl_str_mv |
Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ) |
repository.mail.fl_str_mv |
rgiudici@usp.br||rgiudici@usp.br |
_version_ |
1754213173055979520 |