Modeling for Taxol® Separation in a simulated moving bed

Detalhes bibliográficos
Autor(a) principal: Cremasco,Marco Aurelio
Data de Publicação: 2010
Outros Autores: Starqui,Axel Nicolas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600020
Resumo: This work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol® (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed.
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spelling Modeling for Taxol® Separation in a simulated moving bedCancerTaxolSimulated moving bedComputer simulationMulticomponent separationThis work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol® (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed.Instituto de Tecnologia do Paraná - Tecpar2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600020Brazilian Archives of Biology and Technology v.53 n.6 2010reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132010000600020info:eu-repo/semantics/openAccessCremasco,Marco AurelioStarqui,Axel Nicolaseng2011-01-18T00:00:00Zoai:scielo:S1516-89132010000600020Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2011-01-18T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Modeling for Taxol® Separation in a simulated moving bed
title Modeling for Taxol® Separation in a simulated moving bed
spellingShingle Modeling for Taxol® Separation in a simulated moving bed
Cremasco,Marco Aurelio
Cancer
Taxol
Simulated moving bed
Computer simulation
Multicomponent separation
title_short Modeling for Taxol® Separation in a simulated moving bed
title_full Modeling for Taxol® Separation in a simulated moving bed
title_fullStr Modeling for Taxol® Separation in a simulated moving bed
title_full_unstemmed Modeling for Taxol® Separation in a simulated moving bed
title_sort Modeling for Taxol® Separation in a simulated moving bed
author Cremasco,Marco Aurelio
author_facet Cremasco,Marco Aurelio
Starqui,Axel Nicolas
author_role author
author2 Starqui,Axel Nicolas
author2_role author
dc.contributor.author.fl_str_mv Cremasco,Marco Aurelio
Starqui,Axel Nicolas
dc.subject.por.fl_str_mv Cancer
Taxol
Simulated moving bed
Computer simulation
Multicomponent separation
topic Cancer
Taxol
Simulated moving bed
Computer simulation
Multicomponent separation
description This work presents an alternative numerical resolution strategy for a model to describe the dynamic of linear adsorption processes involving multicomponent mixture of taxanes with Taxol® (paclitaxel), a powerful anti-cancer agent, and non-identified impurities, in a Simulated Moving Bed (SMB) system. To solve the model, a hybrid method were used. The liquid concentration inside the particles was found analytically and was related with the liquid bed concentration using Duhamel's theorem. The results from simulation were compared with experimental ones from the literature, showing a good agreement, which demonstrated the applicability of the model and of the hybrid resolution proposed.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132010000600020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.53 n.6 2010
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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