Transmission of lupus anticoagulant by allogeneic stem cell transplantation

Detalhes bibliográficos
Autor(a) principal: Massoud,Mira Romany
Data de Publicação: 2014
Outros Autores: William,Basem M., Harrill,Katrina, Cooper,Brenda Wimpfheimer, Lima,Marcos de, Schmaier,Alvin H.
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000400287
Resumo: Passive transmission of autoimmune diseases by allogeneic stem cell transplantation is rare and is ascribed to passive transfer of memory B-cells from donor to recipient. We hereby report a case of transmission of an asymptomatic lupus anticoagulant from a sibling donor to a recipient of transplantation for secondary acute myeloid leukemia. On pre-harvest evaluation, the sibling donor with no history of bleeding or thrombosis was found to have a lupus anticoagulant. After engraftment, the recipient was found to have a new prolonged activated partial thromboplastin time and was subsequently shown to have a lupus anticoagulant on Day +73 after stem cell transplantation. The recipient remained well with no evidence of bleeding, thrombosis, or graft-versus-host disease and was on a stable dose of tacrolimus at the time the lupus anticoagulant was detected. There was no other identifiable trigger for the appearance of a lupus anticoagulant.
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spelling Transmission of lupus anticoagulant by allogeneic stem cell transplantationAllogeneic stem cell transplantationLupus anticoagulantActivated partial thromboplastin timePassive transmission of autoimmune diseases by allogeneic stem cell transplantation is rare and is ascribed to passive transfer of memory B-cells from donor to recipient. We hereby report a case of transmission of an asymptomatic lupus anticoagulant from a sibling donor to a recipient of transplantation for secondary acute myeloid leukemia. On pre-harvest evaluation, the sibling donor with no history of bleeding or thrombosis was found to have a lupus anticoagulant. After engraftment, the recipient was found to have a new prolonged activated partial thromboplastin time and was subsequently shown to have a lupus anticoagulant on Day +73 after stem cell transplantation. The recipient remained well with no evidence of bleeding, thrombosis, or graft-versus-host disease and was on a stable dose of tacrolimus at the time the lupus anticoagulant was detected. There was no other identifiable trigger for the appearance of a lupus anticoagulant.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2014-08-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000400287Revista Brasileira de Hematologia e Hemoterapia v.36 n.4 2014reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1016/j.bjhh.2014.05.008info:eu-repo/semantics/openAccessMassoud,Mira RomanyWilliam,Basem M.Harrill,KatrinaCooper,Brenda WimpfheimerLima,Marcos deSchmaier,Alvin H.eng2015-09-22T00:00:00Zoai:scielo:S1516-84842014000400287Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2015-09-22T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Transmission of lupus anticoagulant by allogeneic stem cell transplantation
title Transmission of lupus anticoagulant by allogeneic stem cell transplantation
spellingShingle Transmission of lupus anticoagulant by allogeneic stem cell transplantation
Massoud,Mira Romany
Allogeneic stem cell transplantation
Lupus anticoagulant
Activated partial thromboplastin time
title_short Transmission of lupus anticoagulant by allogeneic stem cell transplantation
title_full Transmission of lupus anticoagulant by allogeneic stem cell transplantation
title_fullStr Transmission of lupus anticoagulant by allogeneic stem cell transplantation
title_full_unstemmed Transmission of lupus anticoagulant by allogeneic stem cell transplantation
title_sort Transmission of lupus anticoagulant by allogeneic stem cell transplantation
author Massoud,Mira Romany
author_facet Massoud,Mira Romany
William,Basem M.
Harrill,Katrina
Cooper,Brenda Wimpfheimer
Lima,Marcos de
Schmaier,Alvin H.
author_role author
author2 William,Basem M.
Harrill,Katrina
Cooper,Brenda Wimpfheimer
Lima,Marcos de
Schmaier,Alvin H.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Massoud,Mira Romany
William,Basem M.
Harrill,Katrina
Cooper,Brenda Wimpfheimer
Lima,Marcos de
Schmaier,Alvin H.
dc.subject.por.fl_str_mv Allogeneic stem cell transplantation
Lupus anticoagulant
Activated partial thromboplastin time
topic Allogeneic stem cell transplantation
Lupus anticoagulant
Activated partial thromboplastin time
description Passive transmission of autoimmune diseases by allogeneic stem cell transplantation is rare and is ascribed to passive transfer of memory B-cells from donor to recipient. We hereby report a case of transmission of an asymptomatic lupus anticoagulant from a sibling donor to a recipient of transplantation for secondary acute myeloid leukemia. On pre-harvest evaluation, the sibling donor with no history of bleeding or thrombosis was found to have a lupus anticoagulant. After engraftment, the recipient was found to have a new prolonged activated partial thromboplastin time and was subsequently shown to have a lupus anticoagulant on Day +73 after stem cell transplantation. The recipient remained well with no evidence of bleeding, thrombosis, or graft-versus-host disease and was on a stable dose of tacrolimus at the time the lupus anticoagulant was detected. There was no other identifiable trigger for the appearance of a lupus anticoagulant.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000400287
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000400287
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjhh.2014.05.008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.36 n.4 2014
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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