Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?

Detalhes bibliográficos
Autor(a) principal: Bacigalupo,Andrea
Data de Publicação: 2009
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800003
Resumo: Allogeneic HSCT was first investigated in selected patients with advanced HD and proved that long-term survival improved for some patients who failed many other lines of therapy. There are 4 studies reporting myeloablative conditioning in preparation for allogeneic HSCT. Although overall survival was above 44%, the high transplant-related mortality convinced most hematologists that allogeneic HSCT was not a real option for patients with HD. The development of reduced intensity conditioning regimens (RIC) in the late nineties, appeared as an opportunity to again test allogeneic HSCT in HD. RIC transplants are associated with significantly lower transplant mortality when compared to myeloablative transplants. However progression free survival is highly dependent on chemoresistance and performance status.
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spelling Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?Hodgkin's diseaseallogeneic stem cell transplantationAllogeneic HSCT was first investigated in selected patients with advanced HD and proved that long-term survival improved for some patients who failed many other lines of therapy. There are 4 studies reporting myeloablative conditioning in preparation for allogeneic HSCT. Although overall survival was above 44%, the high transplant-related mortality convinced most hematologists that allogeneic HSCT was not a real option for patients with HD. The development of reduced intensity conditioning regimens (RIC) in the late nineties, appeared as an opportunity to again test allogeneic HSCT in HD. RIC transplants are associated with significantly lower transplant mortality when compared to myeloablative transplants. However progression free survival is highly dependent on chemoresistance and performance status.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800003Revista Brasileira de Hematologia e Hemoterapia v.31 suppl.2 2009reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1590/S1516-84842009000800003info:eu-repo/semantics/openAccessBacigalupo,Andreaeng2009-09-29T00:00:00Zoai:scielo:S1516-84842009000800003Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2009-09-29T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
title Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
spellingShingle Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
Bacigalupo,Andrea
Hodgkin's disease
allogeneic stem cell transplantation
title_short Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
title_full Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
title_fullStr Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
title_full_unstemmed Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
title_sort Is there a role for allogeneic haemopoietic stem cell transplants (HSCT) in patients with Hodgkin's disease?
author Bacigalupo,Andrea
author_facet Bacigalupo,Andrea
author_role author
dc.contributor.author.fl_str_mv Bacigalupo,Andrea
dc.subject.por.fl_str_mv Hodgkin's disease
allogeneic stem cell transplantation
topic Hodgkin's disease
allogeneic stem cell transplantation
description Allogeneic HSCT was first investigated in selected patients with advanced HD and proved that long-term survival improved for some patients who failed many other lines of therapy. There are 4 studies reporting myeloablative conditioning in preparation for allogeneic HSCT. Although overall survival was above 44%, the high transplant-related mortality convinced most hematologists that allogeneic HSCT was not a real option for patients with HD. The development of reduced intensity conditioning regimens (RIC) in the late nineties, appeared as an opportunity to again test allogeneic HSCT in HD. RIC transplants are associated with significantly lower transplant mortality when compared to myeloablative transplants. However progression free survival is highly dependent on chemoresistance and performance status.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-84842009000800003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.31 suppl.2 2009
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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