Coagulation abnormalities in acute promyelocytic leukemia

Detalhes bibliográficos
Autor(a) principal: Jacomo,Rafael H.
Data de Publicação: 2009
Outros Autores: Rego,Eduardo M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800013
Resumo: Acute promyelocytic leukemia is frequently accompanied by coagulation abnormalities usually described as laboratorial disseminated intravascular coagulation, which is the main cause of morbidity and early mortality. Aberrant activation of the coagulation cascade and hyperfibrinolysis play an important role in the pathogenesis of bleeding diathesis, but their contribution varies from case to case. Here we review the main laboratorial findings and the recommended clinical management of coagulopathy associated with acute promyelocytic leukemia.
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spelling Coagulation abnormalities in acute promyelocytic leukemiaAcute promyelocytic leukemiacoagulationfibrinolysisdisseminated intravascular coagulationAcute promyelocytic leukemia is frequently accompanied by coagulation abnormalities usually described as laboratorial disseminated intravascular coagulation, which is the main cause of morbidity and early mortality. Aberrant activation of the coagulation cascade and hyperfibrinolysis play an important role in the pathogenesis of bleeding diathesis, but their contribution varies from case to case. Here we review the main laboratorial findings and the recommended clinical management of coagulopathy associated with acute promyelocytic leukemia.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800013Revista Brasileira de Hematologia e Hemoterapia v.31 suppl.2 2009reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1590/S1516-84842009000800013info:eu-repo/semantics/openAccessJacomo,Rafael H.Rego,Eduardo M.eng2009-09-29T00:00:00Zoai:scielo:S1516-84842009000800013Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2009-09-29T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Coagulation abnormalities in acute promyelocytic leukemia
title Coagulation abnormalities in acute promyelocytic leukemia
spellingShingle Coagulation abnormalities in acute promyelocytic leukemia
Jacomo,Rafael H.
Acute promyelocytic leukemia
coagulation
fibrinolysis
disseminated intravascular coagulation
title_short Coagulation abnormalities in acute promyelocytic leukemia
title_full Coagulation abnormalities in acute promyelocytic leukemia
title_fullStr Coagulation abnormalities in acute promyelocytic leukemia
title_full_unstemmed Coagulation abnormalities in acute promyelocytic leukemia
title_sort Coagulation abnormalities in acute promyelocytic leukemia
author Jacomo,Rafael H.
author_facet Jacomo,Rafael H.
Rego,Eduardo M.
author_role author
author2 Rego,Eduardo M.
author2_role author
dc.contributor.author.fl_str_mv Jacomo,Rafael H.
Rego,Eduardo M.
dc.subject.por.fl_str_mv Acute promyelocytic leukemia
coagulation
fibrinolysis
disseminated intravascular coagulation
topic Acute promyelocytic leukemia
coagulation
fibrinolysis
disseminated intravascular coagulation
description Acute promyelocytic leukemia is frequently accompanied by coagulation abnormalities usually described as laboratorial disseminated intravascular coagulation, which is the main cause of morbidity and early mortality. Aberrant activation of the coagulation cascade and hyperfibrinolysis play an important role in the pathogenesis of bleeding diathesis, but their contribution varies from case to case. Here we review the main laboratorial findings and the recommended clinical management of coagulopathy associated with acute promyelocytic leukemia.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000800013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-84842009000800013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.31 suppl.2 2009
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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