Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011 |
Resumo: | Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlling the activation of natural killer cells. Several studies have shown that certain combinations of killer immunoglobulin-like receptors and human leukocyte antigens (in both donors and recipients) can affect the chances of survival of transplant patients, particularly in relation to the graft-versusleukemia effect, which may be associated to decreased relapse rates in certain groups. This review aims to shed light on the mechanisms and effects of killer immunoglobulin-like receptors - human leukocyte antigen associations and their implications following hematopoietic stem cell transplantation, and to critically analyze the results obtained by the studies presented herein. |
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Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantationHematopoietic stem cell/transplantationHistocompatibility testingReceptor KIR/immunologyHLA antigensKiller cells, naturalGraft vs host diseaseHematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlling the activation of natural killer cells. Several studies have shown that certain combinations of killer immunoglobulin-like receptors and human leukocyte antigens (in both donors and recipients) can affect the chances of survival of transplant patients, particularly in relation to the graft-versusleukemia effect, which may be associated to decreased relapse rates in certain groups. This review aims to shed light on the mechanisms and effects of killer immunoglobulin-like receptors - human leukocyte antigen associations and their implications following hematopoietic stem cell transplantation, and to critically analyze the results obtained by the studies presented herein.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011Revista Brasileira de Hematologia e Hemoterapia v.33 n.2 2011reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20110033info:eu-repo/semantics/openAccessFranceschi,Danilo Santana AlessioSouza,Cármino Antonio deAranha,Francisco José PenteadoCardozo,Daniela MairaSell,Ana MariaVisentainer,Jeane Eliete Laguilaeng2011-06-21T00:00:00Zoai:scielo:S1516-84842011000200011Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2011-06-21T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation |
title |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation |
spellingShingle |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation Franceschi,Danilo Santana Alessio Hematopoietic stem cell/transplantation Histocompatibility testing Receptor KIR/immunology HLA antigens Killer cells, natural Graft vs host disease |
title_short |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation |
title_full |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation |
title_fullStr |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation |
title_full_unstemmed |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation |
title_sort |
Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation |
author |
Franceschi,Danilo Santana Alessio |
author_facet |
Franceschi,Danilo Santana Alessio Souza,Cármino Antonio de Aranha,Francisco José Penteado Cardozo,Daniela Maira Sell,Ana Maria Visentainer,Jeane Eliete Laguila |
author_role |
author |
author2 |
Souza,Cármino Antonio de Aranha,Francisco José Penteado Cardozo,Daniela Maira Sell,Ana Maria Visentainer,Jeane Eliete Laguila |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Franceschi,Danilo Santana Alessio Souza,Cármino Antonio de Aranha,Francisco José Penteado Cardozo,Daniela Maira Sell,Ana Maria Visentainer,Jeane Eliete Laguila |
dc.subject.por.fl_str_mv |
Hematopoietic stem cell/transplantation Histocompatibility testing Receptor KIR/immunology HLA antigens Killer cells, natural Graft vs host disease |
topic |
Hematopoietic stem cell/transplantation Histocompatibility testing Receptor KIR/immunology HLA antigens Killer cells, natural Graft vs host disease |
description |
Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlling the activation of natural killer cells. Several studies have shown that certain combinations of killer immunoglobulin-like receptors and human leukocyte antigens (in both donors and recipients) can affect the chances of survival of transplant patients, particularly in relation to the graft-versusleukemia effect, which may be associated to decreased relapse rates in certain groups. This review aims to shed light on the mechanisms and effects of killer immunoglobulin-like receptors - human leukocyte antigen associations and their implications following hematopoietic stem cell transplantation, and to critically analyze the results obtained by the studies presented herein. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5581/1516-8484.20110033 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.33 n.2 2011 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
instname_str |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
instacron_str |
ABHHTC |
institution |
ABHHTC |
reponame_str |
Revista brasileira de hematologia e hemoterapia (Online) |
collection |
Revista brasileira de hematologia e hemoterapia (Online) |
repository.name.fl_str_mv |
Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
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1754213111188946944 |