Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation

Detalhes bibliográficos
Autor(a) principal: Franceschi,Danilo Santana Alessio
Data de Publicação: 2011
Outros Autores: Souza,Cármino Antonio de, Aranha,Francisco José Penteado, Cardozo,Daniela Maira, Sell,Ana Maria, Visentainer,Jeane Eliete Laguila
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011
Resumo: Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlling the activation of natural killer cells. Several studies have shown that certain combinations of killer immunoglobulin-like receptors and human leukocyte antigens (in both donors and recipients) can affect the chances of survival of transplant patients, particularly in relation to the graft-versusleukemia effect, which may be associated to decreased relapse rates in certain groups. This review aims to shed light on the mechanisms and effects of killer immunoglobulin-like receptors - human leukocyte antigen associations and their implications following hematopoietic stem cell transplantation, and to critically analyze the results obtained by the studies presented herein.
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spelling Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantationHematopoietic stem cell/transplantationHistocompatibility testingReceptor KIR/immunologyHLA antigensKiller cells, naturalGraft vs host diseaseHematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlling the activation of natural killer cells. Several studies have shown that certain combinations of killer immunoglobulin-like receptors and human leukocyte antigens (in both donors and recipients) can affect the chances of survival of transplant patients, particularly in relation to the graft-versusleukemia effect, which may be associated to decreased relapse rates in certain groups. This review aims to shed light on the mechanisms and effects of killer immunoglobulin-like receptors - human leukocyte antigen associations and their implications following hematopoietic stem cell transplantation, and to critically analyze the results obtained by the studies presented herein.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011Revista Brasileira de Hematologia e Hemoterapia v.33 n.2 2011reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20110033info:eu-repo/semantics/openAccessFranceschi,Danilo Santana AlessioSouza,Cármino Antonio deAranha,Francisco José PenteadoCardozo,Daniela MairaSell,Ana MariaVisentainer,Jeane Eliete Laguilaeng2011-06-21T00:00:00Zoai:scielo:S1516-84842011000200011Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2011-06-21T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
title Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
spellingShingle Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
Franceschi,Danilo Santana Alessio
Hematopoietic stem cell/transplantation
Histocompatibility testing
Receptor KIR/immunology
HLA antigens
Killer cells, natural
Graft vs host disease
title_short Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
title_full Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
title_fullStr Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
title_full_unstemmed Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
title_sort Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
author Franceschi,Danilo Santana Alessio
author_facet Franceschi,Danilo Santana Alessio
Souza,Cármino Antonio de
Aranha,Francisco José Penteado
Cardozo,Daniela Maira
Sell,Ana Maria
Visentainer,Jeane Eliete Laguila
author_role author
author2 Souza,Cármino Antonio de
Aranha,Francisco José Penteado
Cardozo,Daniela Maira
Sell,Ana Maria
Visentainer,Jeane Eliete Laguila
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Franceschi,Danilo Santana Alessio
Souza,Cármino Antonio de
Aranha,Francisco José Penteado
Cardozo,Daniela Maira
Sell,Ana Maria
Visentainer,Jeane Eliete Laguila
dc.subject.por.fl_str_mv Hematopoietic stem cell/transplantation
Histocompatibility testing
Receptor KIR/immunology
HLA antigens
Killer cells, natural
Graft vs host disease
topic Hematopoietic stem cell/transplantation
Histocompatibility testing
Receptor KIR/immunology
HLA antigens
Killer cells, natural
Graft vs host disease
description Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlling the activation of natural killer cells. Several studies have shown that certain combinations of killer immunoglobulin-like receptors and human leukocyte antigens (in both donors and recipients) can affect the chances of survival of transplant patients, particularly in relation to the graft-versusleukemia effect, which may be associated to decreased relapse rates in certain groups. This review aims to shed light on the mechanisms and effects of killer immunoglobulin-like receptors - human leukocyte antigen associations and their implications following hematopoietic stem cell transplantation, and to critically analyze the results obtained by the studies presented herein.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5581/1516-8484.20110033
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.33 n.2 2011
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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