Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200008 |
Resumo: | BACKGROUND: The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways. OBJECTIVE: To assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law. METHODS: Whole blood samples from 80 donors and the respective platelet concentrate units were tested. Platelet concentrates were tested (platelet count, aggregation and pH) on days 1, 3 and 5 of storage. Additionally a leukocyte count was done only on day 1 and microbiological tests on day 5 of storage. Collagen and adenosine diphosphate were used as inducing agonists for platelet aggregation testing. RESULTS: Donor whole blood had normal aggregation (aggregation with adenosine diphosphate = 67% and with collagen = 78%). The median aggregation in platelet concentrates with adenosine diphosphate was low throughout storage (18% on day 1, 7% on day 3 and 6% on day 5) and the median aggregation with collagen was normal only on day 1 and low thereafter (54.4% on day 1, 20.5% on day 3 and 9% on day 5). CONCLUSION: Although the results were within the norms required by law, platelet concentrates had low aggregation rates. We suggest the inclusion of a functional assessment test for the quality control of platelet concentrates for a more effective response to platelet replacement therapy. |
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Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood BankHemostasisQuality controlCollagenBlood component transfusionBlood banksPlatelet aggregationBACKGROUND: The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways. OBJECTIVE: To assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law. METHODS: Whole blood samples from 80 donors and the respective platelet concentrate units were tested. Platelet concentrates were tested (platelet count, aggregation and pH) on days 1, 3 and 5 of storage. Additionally a leukocyte count was done only on day 1 and microbiological tests on day 5 of storage. Collagen and adenosine diphosphate were used as inducing agonists for platelet aggregation testing. RESULTS: Donor whole blood had normal aggregation (aggregation with adenosine diphosphate = 67% and with collagen = 78%). The median aggregation in platelet concentrates with adenosine diphosphate was low throughout storage (18% on day 1, 7% on day 3 and 6% on day 5) and the median aggregation with collagen was normal only on day 1 and low thereafter (54.4% on day 1, 20.5% on day 3 and 9% on day 5). CONCLUSION: Although the results were within the norms required by law, platelet concentrates had low aggregation rates. We suggest the inclusion of a functional assessment test for the quality control of platelet concentrates for a more effective response to platelet replacement therapy.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200008Revista Brasileira de Hematologia e Hemoterapia v.33 n.2 2011reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20110030info:eu-repo/semantics/openAccessCoêlho,Maria José DantasMonteiro,Taysa de CastroVasquez,Felicien GonçalvesSilva,Kátia Luz TorresSantos,Kleber Sandro Brasil dosOliveira,Viviana Maria Araújo deCavalcante,Francimary de Oliveiraeng2011-06-13T00:00:00Zoai:scielo:S1516-84842011000200008Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2011-06-13T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank |
title |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank |
spellingShingle |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank Coêlho,Maria José Dantas Hemostasis Quality control Collagen Blood component transfusion Blood banks Platelet aggregation |
title_short |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank |
title_full |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank |
title_fullStr |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank |
title_full_unstemmed |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank |
title_sort |
Platelet aggregation and quality control of platelet concentrates produced in the Amazon Blood Bank |
author |
Coêlho,Maria José Dantas |
author_facet |
Coêlho,Maria José Dantas Monteiro,Taysa de Castro Vasquez,Felicien Gonçalves Silva,Kátia Luz Torres Santos,Kleber Sandro Brasil dos Oliveira,Viviana Maria Araújo de Cavalcante,Francimary de Oliveira |
author_role |
author |
author2 |
Monteiro,Taysa de Castro Vasquez,Felicien Gonçalves Silva,Kátia Luz Torres Santos,Kleber Sandro Brasil dos Oliveira,Viviana Maria Araújo de Cavalcante,Francimary de Oliveira |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Coêlho,Maria José Dantas Monteiro,Taysa de Castro Vasquez,Felicien Gonçalves Silva,Kátia Luz Torres Santos,Kleber Sandro Brasil dos Oliveira,Viviana Maria Araújo de Cavalcante,Francimary de Oliveira |
dc.subject.por.fl_str_mv |
Hemostasis Quality control Collagen Blood component transfusion Blood banks Platelet aggregation |
topic |
Hemostasis Quality control Collagen Blood component transfusion Blood banks Platelet aggregation |
description |
BACKGROUND: The study of platelet aggregation is essential to assess in vitro platelet function by different platelet activation pathways. OBJECTIVE: To assess aggregation and biochemical parameters of random platelet concentrates produced at the Fundação HEMOAM using the quality control tests defined by law. METHODS: Whole blood samples from 80 donors and the respective platelet concentrate units were tested. Platelet concentrates were tested (platelet count, aggregation and pH) on days 1, 3 and 5 of storage. Additionally a leukocyte count was done only on day 1 and microbiological tests on day 5 of storage. Collagen and adenosine diphosphate were used as inducing agonists for platelet aggregation testing. RESULTS: Donor whole blood had normal aggregation (aggregation with adenosine diphosphate = 67% and with collagen = 78%). The median aggregation in platelet concentrates with adenosine diphosphate was low throughout storage (18% on day 1, 7% on day 3 and 6% on day 5) and the median aggregation with collagen was normal only on day 1 and low thereafter (54.4% on day 1, 20.5% on day 3 and 9% on day 5). CONCLUSION: Although the results were within the norms required by law, platelet concentrates had low aggregation rates. We suggest the inclusion of a functional assessment test for the quality control of platelet concentrates for a more effective response to platelet replacement therapy. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5581/1516-8484.20110030 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.33 n.2 2011 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
instname_str |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
instacron_str |
ABHHTC |
institution |
ABHHTC |
reponame_str |
Revista brasileira de hematologia e hemoterapia (Online) |
collection |
Revista brasileira de hematologia e hemoterapia (Online) |
repository.name.fl_str_mv |
Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
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1754213111183704064 |