Resistance of dialyzed patients to erythropoietin

Detalhes bibliográficos
Autor(a) principal: Alves,Michelle Teodoro
Data de Publicação: 2015
Outros Autores: Vilaça,Sandra Simone, Carvalho,Maria das Graças, Fernandes,Ana Paula, Dusse,Luci Maria Sant'Ana, Gomes,Karina Braga
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000300190
Resumo: Resistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these patients is iron deficiency. However, a high proportion of patients does not respond to treatment, even to the use of intravenous iron, which indicates the presence of other important causes of resistance. In addition to the iron deficiency, the most common causes of resistance include inflammation, infection, malnutrition, inadequate dialysis, and hyperparathyroidism, although other factors may be associated. In the presence of adequate iron stores, other causes should be investigated and treated appropriately.
id ABHHTC-1_c983a5d7c30be10c0a7fbd9d80aced96
oai_identifier_str oai:scielo:S1516-84842015000300190
network_acronym_str ABHHTC-1
network_name_str Revista brasileira de hematologia e hemoterapia (Online)
repository_id_str
spelling Resistance of dialyzed patients to erythropoietinDialysisErythropoietinIronResistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these patients is iron deficiency. However, a high proportion of patients does not respond to treatment, even to the use of intravenous iron, which indicates the presence of other important causes of resistance. In addition to the iron deficiency, the most common causes of resistance include inflammation, infection, malnutrition, inadequate dialysis, and hyperparathyroidism, although other factors may be associated. In the presence of adequate iron stores, other causes should be investigated and treated appropriately.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000300190Revista Brasileira de Hematologia e Hemoterapia v.37 n.3 2015reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1016/j.bjhh.2015.02.001info:eu-repo/semantics/openAccessAlves,Michelle TeodoroVilaça,Sandra SimoneCarvalho,Maria das GraçasFernandes,Ana PaulaDusse,Luci Maria Sant'AnaGomes,Karina Bragaeng2015-07-17T00:00:00Zoai:scielo:S1516-84842015000300190Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2015-07-17T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Resistance of dialyzed patients to erythropoietin
title Resistance of dialyzed patients to erythropoietin
spellingShingle Resistance of dialyzed patients to erythropoietin
Alves,Michelle Teodoro
Dialysis
Erythropoietin
Iron
title_short Resistance of dialyzed patients to erythropoietin
title_full Resistance of dialyzed patients to erythropoietin
title_fullStr Resistance of dialyzed patients to erythropoietin
title_full_unstemmed Resistance of dialyzed patients to erythropoietin
title_sort Resistance of dialyzed patients to erythropoietin
author Alves,Michelle Teodoro
author_facet Alves,Michelle Teodoro
Vilaça,Sandra Simone
Carvalho,Maria das Graças
Fernandes,Ana Paula
Dusse,Luci Maria Sant'Ana
Gomes,Karina Braga
author_role author
author2 Vilaça,Sandra Simone
Carvalho,Maria das Graças
Fernandes,Ana Paula
Dusse,Luci Maria Sant'Ana
Gomes,Karina Braga
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Alves,Michelle Teodoro
Vilaça,Sandra Simone
Carvalho,Maria das Graças
Fernandes,Ana Paula
Dusse,Luci Maria Sant'Ana
Gomes,Karina Braga
dc.subject.por.fl_str_mv Dialysis
Erythropoietin
Iron
topic Dialysis
Erythropoietin
Iron
description Resistance to recombinant human erythropoietin is a common condition in dialyzed patients with chronic kidney disease and is associated with more hospitalizations, increased mortality and frequent blood transfusions. The main cause of hyporesponsiveness to recombinant human erythropoietin in these patients is iron deficiency. However, a high proportion of patients does not respond to treatment, even to the use of intravenous iron, which indicates the presence of other important causes of resistance. In addition to the iron deficiency, the most common causes of resistance include inflammation, infection, malnutrition, inadequate dialysis, and hyperparathyroidism, although other factors may be associated. In the presence of adequate iron stores, other causes should be investigated and treated appropriately.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000300190
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842015000300190
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjhh.2015.02.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.37 n.3 2015
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
_version_ 1754213112465063936

Registros relacionados