Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma

Detalhes bibliográficos
Autor(a) principal: Rocha Filho,Francisco D.
Data de Publicação: 2008
Outros Autores: Lima,Gabrielle G., Ferreira,Francisco V., Miranda,Nadjane B. A., Santos,Franklin J. C., Vieira,Andrea A., Messias,Nídia C.
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Revista brasileira de hematologia e hemoterapia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000500020
Resumo: Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been reported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21)(q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.
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spelling Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcomaGranulocytic sarcomabreastacute myeloid leukemiaGranulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been reported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21)(q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2008-10-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000500020Revista Brasileira de Hematologia e Hemoterapia v.30 n.5 2008reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.1590/S1516-84842008000500020info:eu-repo/semantics/openAccessRocha Filho,Francisco D.Lima,Gabrielle G.Ferreira,Francisco V.Miranda,Nadjane B. A.Santos,Franklin J. C.Vieira,Andrea A.Messias,Nídia C.eng2008-12-16T00:00:00Zoai:scielo:S1516-84842008000500020Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2008-12-16T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false
dc.title.none.fl_str_mv Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
spellingShingle Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
Rocha Filho,Francisco D.
Granulocytic sarcoma
breast
acute myeloid leukemia
title_short Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_full Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_fullStr Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_full_unstemmed Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_sort Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
author Rocha Filho,Francisco D.
author_facet Rocha Filho,Francisco D.
Lima,Gabrielle G.
Ferreira,Francisco V.
Miranda,Nadjane B. A.
Santos,Franklin J. C.
Vieira,Andrea A.
Messias,Nídia C.
author_role author
author2 Lima,Gabrielle G.
Ferreira,Francisco V.
Miranda,Nadjane B. A.
Santos,Franklin J. C.
Vieira,Andrea A.
Messias,Nídia C.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha Filho,Francisco D.
Lima,Gabrielle G.
Ferreira,Francisco V.
Miranda,Nadjane B. A.
Santos,Franklin J. C.
Vieira,Andrea A.
Messias,Nídia C.
dc.subject.por.fl_str_mv Granulocytic sarcoma
breast
acute myeloid leukemia
topic Granulocytic sarcoma
breast
acute myeloid leukemia
description Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been reported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21)(q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.
publishDate 2008
dc.date.none.fl_str_mv 2008-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000500020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000500020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-84842008000500020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publisher.none.fl_str_mv Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
dc.source.none.fl_str_mv Revista Brasileira de Hematologia e Hemoterapia v.30 n.5 2008
reponame:Revista brasileira de hematologia e hemoterapia (Online)
instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
instname_str Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron_str ABHHTC
institution ABHHTC
reponame_str Revista brasileira de hematologia e hemoterapia (Online)
collection Revista brasileira de hematologia e hemoterapia (Online)
repository.name.fl_str_mv Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
repository.mail.fl_str_mv sbhh@terra.com.br||secretaria@rbhh.org
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