Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Materials research (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392020000500202 |
Resumo: | Abstract Composite materials are used in bone tissue engineering because they mimic the structure of the extracellular matrix of bone. In this work, polylactic acid (PLA) fiber scaffolds prepared by air-jet spinning technique, were doped with different concentrations of SBA-15 ceramic (0.05, 0.1, and 0.15 wt%). The SBA-15 ceramic powder was made by the Sol-Gel process. Physicochemical characterization of PLA, SBA-15, and composite fiber scaffold was done by XRD, SEM, BET, FTIR, TGA, mechanical test, and biocompatibility assay, which were performed in a cell culture model with osteoblast cells. Our results showed a random nanofibers composite scaffold with an improvement in the physicochemical properties. The PLA fiber diameter increases as increases the content of SBA-15, and the mechanical properties were dose-dependent. SBA-15 shows the well-ordered mesoporous hexagonal structure with a pore size of 5.8 ± 0.2 nm and a specific surface area with a value of 1042 ± 89 m2/g. PLAfibers and composites have thermal stability up to 300°C, and thermal decomposition in the range 316-367°C. In vitro biocompatibility results showed that PLA/SBA-15 composite scaffold had no cytotoxicity effect in terms of cell adhesion and viability of osteoblast cells. Furthermore, the doped SBA-15 with 0.05% wt onto the polymer matrix could be useful in biomedical applications for bone tissue engineering. |
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Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue EngineeringSilica mesoporous materialair-jet spinningfiber spun matscomposites scaffoldcell-material interactionbone tissue engineeringAbstract Composite materials are used in bone tissue engineering because they mimic the structure of the extracellular matrix of bone. In this work, polylactic acid (PLA) fiber scaffolds prepared by air-jet spinning technique, were doped with different concentrations of SBA-15 ceramic (0.05, 0.1, and 0.15 wt%). The SBA-15 ceramic powder was made by the Sol-Gel process. Physicochemical characterization of PLA, SBA-15, and composite fiber scaffold was done by XRD, SEM, BET, FTIR, TGA, mechanical test, and biocompatibility assay, which were performed in a cell culture model with osteoblast cells. Our results showed a random nanofibers composite scaffold with an improvement in the physicochemical properties. The PLA fiber diameter increases as increases the content of SBA-15, and the mechanical properties were dose-dependent. SBA-15 shows the well-ordered mesoporous hexagonal structure with a pore size of 5.8 ± 0.2 nm and a specific surface area with a value of 1042 ± 89 m2/g. PLAfibers and composites have thermal stability up to 300°C, and thermal decomposition in the range 316-367°C. In vitro biocompatibility results showed that PLA/SBA-15 composite scaffold had no cytotoxicity effect in terms of cell adhesion and viability of osteoblast cells. Furthermore, the doped SBA-15 with 0.05% wt onto the polymer matrix could be useful in biomedical applications for bone tissue engineering.ABM, ABC, ABPol2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392020000500202Materials Research v.23 n.5 2020reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1980-5373-mr-2020-0211info:eu-repo/semantics/openAccessChanes-Cuevas,Osmar AlejandroArellano-Sánchez,UlisesÁlvarez-Gayosso,Carlos AndrésSuaste-Olmos,FernandoVillarreal-Ramírez,EduardoÁlvarez-Fregoso,OctavioGarcía-Hipólito,ManuelGonzález-Alva,PatriciaÁlvarez-Pérez,Marco A.eng2020-10-07T00:00:00Zoai:scielo:S1516-14392020000500202Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2020-10-07T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.none.fl_str_mv |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering |
title |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering |
spellingShingle |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering Chanes-Cuevas,Osmar Alejandro Silica mesoporous material air-jet spinning fiber spun mats composites scaffold cell-material interaction bone tissue engineering |
title_short |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering |
title_full |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering |
title_fullStr |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering |
title_full_unstemmed |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering |
title_sort |
Synthesis of PLA/SBA-15 Composite Scaffolds for Bone Tissue Engineering |
author |
Chanes-Cuevas,Osmar Alejandro |
author_facet |
Chanes-Cuevas,Osmar Alejandro Arellano-Sánchez,Ulises Álvarez-Gayosso,Carlos Andrés Suaste-Olmos,Fernando Villarreal-Ramírez,Eduardo Álvarez-Fregoso,Octavio García-Hipólito,Manuel González-Alva,Patricia Álvarez-Pérez,Marco A. |
author_role |
author |
author2 |
Arellano-Sánchez,Ulises Álvarez-Gayosso,Carlos Andrés Suaste-Olmos,Fernando Villarreal-Ramírez,Eduardo Álvarez-Fregoso,Octavio García-Hipólito,Manuel González-Alva,Patricia Álvarez-Pérez,Marco A. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Chanes-Cuevas,Osmar Alejandro Arellano-Sánchez,Ulises Álvarez-Gayosso,Carlos Andrés Suaste-Olmos,Fernando Villarreal-Ramírez,Eduardo Álvarez-Fregoso,Octavio García-Hipólito,Manuel González-Alva,Patricia Álvarez-Pérez,Marco A. |
dc.subject.por.fl_str_mv |
Silica mesoporous material air-jet spinning fiber spun mats composites scaffold cell-material interaction bone tissue engineering |
topic |
Silica mesoporous material air-jet spinning fiber spun mats composites scaffold cell-material interaction bone tissue engineering |
description |
Abstract Composite materials are used in bone tissue engineering because they mimic the structure of the extracellular matrix of bone. In this work, polylactic acid (PLA) fiber scaffolds prepared by air-jet spinning technique, were doped with different concentrations of SBA-15 ceramic (0.05, 0.1, and 0.15 wt%). The SBA-15 ceramic powder was made by the Sol-Gel process. Physicochemical characterization of PLA, SBA-15, and composite fiber scaffold was done by XRD, SEM, BET, FTIR, TGA, mechanical test, and biocompatibility assay, which were performed in a cell culture model with osteoblast cells. Our results showed a random nanofibers composite scaffold with an improvement in the physicochemical properties. The PLA fiber diameter increases as increases the content of SBA-15, and the mechanical properties were dose-dependent. SBA-15 shows the well-ordered mesoporous hexagonal structure with a pore size of 5.8 ± 0.2 nm and a specific surface area with a value of 1042 ± 89 m2/g. PLAfibers and composites have thermal stability up to 300°C, and thermal decomposition in the range 316-367°C. In vitro biocompatibility results showed that PLA/SBA-15 composite scaffold had no cytotoxicity effect in terms of cell adhesion and viability of osteoblast cells. Furthermore, the doped SBA-15 with 0.05% wt onto the polymer matrix could be useful in biomedical applications for bone tissue engineering. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392020000500202 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392020000500202 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1980-5373-mr-2020-0211 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABM, ABC, ABPol |
publisher.none.fl_str_mv |
ABM, ABC, ABPol |
dc.source.none.fl_str_mv |
Materials Research v.23 n.5 2020 reponame:Materials research (São Carlos. Online) instname:Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
ABM ABC ABPOL |
institution |
ABM ABC ABPOL |
reponame_str |
Materials research (São Carlos. Online) |
collection |
Materials research (São Carlos. Online) |
repository.name.fl_str_mv |
Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
dedz@power.ufscar.br |
_version_ |
1754212677753765888 |