Preparation and characterization of hydrogels with potential for use as biomaterials

Detalhes bibliográficos
Autor(a) principal: Thürmer,Mônica Beatriz
Data de Publicação: 2014
Outros Autores: Diehl,Carlos Eduardo, Brum,Fábio José Bento, Santos,Luís Alberto dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700018
Resumo: Hydrogels have been extensively explored for biomedical applications due to their ability to absorb high water content in its structure, which gives excellent biocompatibility. This work aims at obtaining biocompatible hydrogels with potential for use in increasing the mechanical strength of bone substitutes, or controlled drug release. Poly (N-vinyl-2-pyrrolidone) hydrogels were prepared by free radical polymerization with and without the addition of acrylic acid. Azobisisobutyronitrile and ammonium persulfate were used as initiator and N,N-methylenebisacrylamide was used as the crosslinking agent. The characterization of the hydrogels was performed by thermogravimetric analysis, differential scanning calorimetry, infrared spectroscopy and swelling properties. The results obtained demonstrate different degrees of crosslinking and swelling of up to 490 ± 30%. The different properties of the hydrogels suggest different applications.
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spelling Preparation and characterization of hydrogels with potential for use as biomaterialsbiocompatiblehydrogelPVPPAApolymerizationHydrogels have been extensively explored for biomedical applications due to their ability to absorb high water content in its structure, which gives excellent biocompatibility. This work aims at obtaining biocompatible hydrogels with potential for use in increasing the mechanical strength of bone substitutes, or controlled drug release. Poly (N-vinyl-2-pyrrolidone) hydrogels were prepared by free radical polymerization with and without the addition of acrylic acid. Azobisisobutyronitrile and ammonium persulfate were used as initiator and N,N-methylenebisacrylamide was used as the crosslinking agent. The characterization of the hydrogels was performed by thermogravimetric analysis, differential scanning calorimetry, infrared spectroscopy and swelling properties. The results obtained demonstrate different degrees of crosslinking and swelling of up to 490 ± 30%. The different properties of the hydrogels suggest different applications.ABM, ABC, ABPol2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700018Materials Research v.17 suppl.1 2014reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1516-1439.223613info:eu-repo/semantics/openAccessThürmer,Mônica BeatrizDiehl,Carlos EduardoBrum,Fábio José BentoSantos,Luís Alberto doseng2015-11-06T00:00:00Zoai:scielo:S1516-14392014000700018Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2015-11-06T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Preparation and characterization of hydrogels with potential for use as biomaterials
title Preparation and characterization of hydrogels with potential for use as biomaterials
spellingShingle Preparation and characterization of hydrogels with potential for use as biomaterials
Thürmer,Mônica Beatriz
biocompatible
hydrogel
PVP
PAA
polymerization
title_short Preparation and characterization of hydrogels with potential for use as biomaterials
title_full Preparation and characterization of hydrogels with potential for use as biomaterials
title_fullStr Preparation and characterization of hydrogels with potential for use as biomaterials
title_full_unstemmed Preparation and characterization of hydrogels with potential for use as biomaterials
title_sort Preparation and characterization of hydrogels with potential for use as biomaterials
author Thürmer,Mônica Beatriz
author_facet Thürmer,Mônica Beatriz
Diehl,Carlos Eduardo
Brum,Fábio José Bento
Santos,Luís Alberto dos
author_role author
author2 Diehl,Carlos Eduardo
Brum,Fábio José Bento
Santos,Luís Alberto dos
author2_role author
author
author
dc.contributor.author.fl_str_mv Thürmer,Mônica Beatriz
Diehl,Carlos Eduardo
Brum,Fábio José Bento
Santos,Luís Alberto dos
dc.subject.por.fl_str_mv biocompatible
hydrogel
PVP
PAA
polymerization
topic biocompatible
hydrogel
PVP
PAA
polymerization
description Hydrogels have been extensively explored for biomedical applications due to their ability to absorb high water content in its structure, which gives excellent biocompatibility. This work aims at obtaining biocompatible hydrogels with potential for use in increasing the mechanical strength of bone substitutes, or controlled drug release. Poly (N-vinyl-2-pyrrolidone) hydrogels were prepared by free radical polymerization with and without the addition of acrylic acid. Azobisisobutyronitrile and ammonium persulfate were used as initiator and N,N-methylenebisacrylamide was used as the crosslinking agent. The characterization of the hydrogels was performed by thermogravimetric analysis, differential scanning calorimetry, infrared spectroscopy and swelling properties. The results obtained demonstrate different degrees of crosslinking and swelling of up to 490 ± 30%. The different properties of the hydrogels suggest different applications.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1516-1439.223613
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.17 suppl.1 2014
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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