Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Materials research (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100027 |
Resumo: | The proper healing of bone defects requires a bone graft or bone substitute and synthetic materials have been developed as alternatives to autografts and allografts. Poly(DL-lactic-co-glycolic acid) (PLGA) is a synthetic polymer widely used for bone healing because of its biocompatibility and biodegradability. PLGA scaffolds have also been used in drug delivery devices, such as in combination with simvastatin, to stimulate bone growth. In this work, we examined the usefulness of a combination of PLGA with simvastatin for treating bone defects. For this, two defects were created in rat calvaria and in half of the animals the right sides were filled with PLGA scaffolds while the other half received PLGA plus simvastatin; the left sides remained empty. The rats were killed for histological analysis after four and eight weeks. There was a significant increase in the amount of bone formation in the treated lesions, particularly those that received PLGA plus simvastatin. |
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Materials research (São Carlos. Online) |
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Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defectsbone regenerationPLGAsimvastatintissue engineeringThe proper healing of bone defects requires a bone graft or bone substitute and synthetic materials have been developed as alternatives to autografts and allografts. Poly(DL-lactic-co-glycolic acid) (PLGA) is a synthetic polymer widely used for bone healing because of its biocompatibility and biodegradability. PLGA scaffolds have also been used in drug delivery devices, such as in combination with simvastatin, to stimulate bone growth. In this work, we examined the usefulness of a combination of PLGA with simvastatin for treating bone defects. For this, two defects were created in rat calvaria and in half of the animals the right sides were filled with PLGA scaffolds while the other half received PLGA plus simvastatin; the left sides remained empty. The rats were killed for histological analysis after four and eight weeks. There was a significant increase in the amount of bone formation in the treated lesions, particularly those that received PLGA plus simvastatin.ABM, ABC, ABPol2013-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100027Materials Research v.16 n.1 2013reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/S1516-14392012005000159info:eu-repo/semantics/openAccessAssaf,KylDuek,Eliana Aparecida de RezendeOliveira,Newton Macieleng2013-01-31T00:00:00Zoai:scielo:S1516-14392013000100027Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2013-01-31T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.none.fl_str_mv |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects |
title |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects |
spellingShingle |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects Assaf,Kyl bone regeneration PLGA simvastatin tissue engineering |
title_short |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects |
title_full |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects |
title_fullStr |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects |
title_full_unstemmed |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects |
title_sort |
Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of Bone Defects |
author |
Assaf,Kyl |
author_facet |
Assaf,Kyl Duek,Eliana Aparecida de Rezende Oliveira,Newton Maciel |
author_role |
author |
author2 |
Duek,Eliana Aparecida de Rezende Oliveira,Newton Maciel |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Assaf,Kyl Duek,Eliana Aparecida de Rezende Oliveira,Newton Maciel |
dc.subject.por.fl_str_mv |
bone regeneration PLGA simvastatin tissue engineering |
topic |
bone regeneration PLGA simvastatin tissue engineering |
description |
The proper healing of bone defects requires a bone graft or bone substitute and synthetic materials have been developed as alternatives to autografts and allografts. Poly(DL-lactic-co-glycolic acid) (PLGA) is a synthetic polymer widely used for bone healing because of its biocompatibility and biodegradability. PLGA scaffolds have also been used in drug delivery devices, such as in combination with simvastatin, to stimulate bone growth. In this work, we examined the usefulness of a combination of PLGA with simvastatin for treating bone defects. For this, two defects were created in rat calvaria and in half of the animals the right sides were filled with PLGA scaffolds while the other half received PLGA plus simvastatin; the left sides remained empty. The rats were killed for histological analysis after four and eight weeks. There was a significant increase in the amount of bone formation in the treated lesions, particularly those that received PLGA plus simvastatin. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100027 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392013000100027 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-14392012005000159 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABM, ABC, ABPol |
publisher.none.fl_str_mv |
ABM, ABC, ABPol |
dc.source.none.fl_str_mv |
Materials Research v.16 n.1 2013 reponame:Materials research (São Carlos. Online) instname:Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
ABM ABC ABPOL |
institution |
ABM ABC ABPOL |
reponame_str |
Materials research (São Carlos. Online) |
collection |
Materials research (São Carlos. Online) |
repository.name.fl_str_mv |
Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
dedz@power.ufscar.br |
_version_ |
1754212662050291712 |