Cartilage reconstruction using self-anchoring implant with functional gradient

• Autor(a) principal: Laurenti,Karen Cristina
• Data de Publicação: 2014
• Outros Autores: Haach,Lourdes Cristina de Albuquerque, Santos Jr.,Arnaldo Rodrigues dos, Rollo,João Manuel Domingos de Almeida, Reiff,Rodrigo Bezerra de Menezes, Gaspar,Ana Maria Minarelli, Purquerio,Benedito de Moraes, Fortulan,Carlos Alberto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Materials research (São Carlos. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000300015
• topic: osteochondral defect; polyurethane; microfiber 45S5 bioglass; cartilage repair; functional gradient

This study presents an innovative and original biomaterial designed to substitute for articular cartilage and mimic its mechanical behavior, including elastic cushioning and the characteristics of fiber-reinforced gel. The material was composed of polyurethane and bioglass microfiber 45S5. It was designed to present a tribological surface to the cartilage of the tibial plateau, and to convert over a functional gradient to an osteointegrable region for self-anchorage to the subchondral bone. The biomaterial samples showed no toxicity and promoted cell spreading. Subsequent in vivo studies in rabbits demonstrated the formation of a rigid structure similar to bone trabeculae in the distal region of the tribological surface of the implant. The tribological surface of the proximal region showed a fibrocartilaginous tissue with highly vascularized chondrocytes, thus validating the proposed concept for the design of the implant incorporating a functional gradient and auto-stability.