Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient

Detalhes bibliográficos
Autor(a) principal: Laurenti, Karen Cristina
Data de Publicação: 2014
Outros Autores: Albuquerque Haach, Lourdes Cristina de, Santos, Arnaldo Rodrigues dos, Domingos de Almeida Rollo, Joao Manuel, Menezes Reiff, Rodrigo Bezerra de, Minarelli Gaspar, Ana Maria [UNESP], Purquerio, Benedito de Moraes, Fortulan, Carlos Alberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1516-14392014005000030
http://hdl.handle.net/11449/112558
Resumo: This study presents an innovative and original biomaterial designed to substitute for articular cartilage and mimic its mechanical behavior, including elastic cushioning and the characteristics of fiber-reinforced gel. The material was composed of polyurethane and bioglass microfiber 45S5. It was designed to present a tribological surface to the cartilage of the tibial plateau, and to convert over a functional gradient to an osteointegrable region for self-anchorage to the subchondral bone. The biomaterial samples showed no toxicity and promoted cell spreading. Subsequent in vivo studies in rabbits demonstrated the formation of a rigid structure similar to bone trabeculae in the distal region of the tribological surface of the implant. The tribological surface of the proximal region showed a fibrocartilaginous tissue with highly vascularized chondrocytes, thus validating the proposed concept for the design of the implant incorporating a functional gradient and auto-stability.
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spelling Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradientosteochondral defectpolyurethanemicrofiber 45S5 bioglasscartilage repairfunctional gradientThis study presents an innovative and original biomaterial designed to substitute for articular cartilage and mimic its mechanical behavior, including elastic cushioning and the characteristics of fiber-reinforced gel. The material was composed of polyurethane and bioglass microfiber 45S5. It was designed to present a tribological surface to the cartilage of the tibial plateau, and to convert over a functional gradient to an osteointegrable region for self-anchorage to the subchondral bone. The biomaterial samples showed no toxicity and promoted cell spreading. Subsequent in vivo studies in rabbits demonstrated the formation of a rigid structure similar to bone trabeculae in the distal region of the tribological surface of the implant. The tribological surface of the proximal region showed a fibrocartilaginous tissue with highly vascularized chondrocytes, thus validating the proposed concept for the design of the implant incorporating a functional gradient and auto-stability.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Sao Paulo, Dept Mech Engn, BR-13566590 Sao Carlos, SP, BrazilUniv ABC, Ctr Nat Sci & Humanities, BR-09210971 Santo Andre, SP, BrazilUniv Sao Paulo, Bioengn Interunits, BR-13566590 Sao Carlos, SP, BrazilFed Univ Sao Carlos UFSCar, BR-13565905 Sao Carlos, SP, BrazilUniv Estadual Paulista Julio de Mesquita, UNESP, Lab Morfol, BR-14801903 Sao Paulo, BrazilUniv Estadual Paulista Julio de Mesquita, UNESP, Lab Morfol, BR-14801903 Sao Paulo, BrazilCAPES: PE 0652008481500/2007-3Univ Fed Sao Carlos, Dept Engenharia MaterialsUniversidade de São Paulo (USP)Univ ABCUniversidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)Laurenti, Karen CristinaAlbuquerque Haach, Lourdes Cristina deSantos, Arnaldo Rodrigues dosDomingos de Almeida Rollo, Joao ManuelMenezes Reiff, Rodrigo Bezerra deMinarelli Gaspar, Ana Maria [UNESP]Purquerio, Benedito de MoraesFortulan, Carlos Alberto2014-12-03T13:10:49Z2014-12-03T13:10:49Z2014-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article638-649application/pdfhttp://dx.doi.org/10.1590/S1516-14392014005000030Materials Research-ibero-american Journal Of Materials. Sao Carlos: Univ Fed Sao Carlos, Dept Engenharia Materials, v. 17, n. 3, p. 638-649, 2014.1516-1439http://hdl.handle.net/11449/11255810.1590/S1516-14392014005000030S1516-14392014005000030WOS:000338017600015S1516-14392014000300015.pdf8379925533335630Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Research-ibero-american Journal of Materials1.1030,398info:eu-repo/semantics/openAccess2024-01-22T06:21:34Zoai:repositorio.unesp.br:11449/112558Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:38:22.997260Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
title Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
spellingShingle Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
Laurenti, Karen Cristina
osteochondral defect
polyurethane
microfiber 45S5 bioglass
cartilage repair
functional gradient
title_short Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
title_full Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
title_fullStr Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
title_full_unstemmed Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
title_sort Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient
author Laurenti, Karen Cristina
author_facet Laurenti, Karen Cristina
Albuquerque Haach, Lourdes Cristina de
Santos, Arnaldo Rodrigues dos
Domingos de Almeida Rollo, Joao Manuel
Menezes Reiff, Rodrigo Bezerra de
Minarelli Gaspar, Ana Maria [UNESP]
Purquerio, Benedito de Moraes
Fortulan, Carlos Alberto
author_role author
author2 Albuquerque Haach, Lourdes Cristina de
Santos, Arnaldo Rodrigues dos
Domingos de Almeida Rollo, Joao Manuel
Menezes Reiff, Rodrigo Bezerra de
Minarelli Gaspar, Ana Maria [UNESP]
Purquerio, Benedito de Moraes
Fortulan, Carlos Alberto
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Univ ABC
Universidade Federal de São Carlos (UFSCar)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Laurenti, Karen Cristina
Albuquerque Haach, Lourdes Cristina de
Santos, Arnaldo Rodrigues dos
Domingos de Almeida Rollo, Joao Manuel
Menezes Reiff, Rodrigo Bezerra de
Minarelli Gaspar, Ana Maria [UNESP]
Purquerio, Benedito de Moraes
Fortulan, Carlos Alberto
dc.subject.por.fl_str_mv osteochondral defect
polyurethane
microfiber 45S5 bioglass
cartilage repair
functional gradient
topic osteochondral defect
polyurethane
microfiber 45S5 bioglass
cartilage repair
functional gradient
description This study presents an innovative and original biomaterial designed to substitute for articular cartilage and mimic its mechanical behavior, including elastic cushioning and the characteristics of fiber-reinforced gel. The material was composed of polyurethane and bioglass microfiber 45S5. It was designed to present a tribological surface to the cartilage of the tibial plateau, and to convert over a functional gradient to an osteointegrable region for self-anchorage to the subchondral bone. The biomaterial samples showed no toxicity and promoted cell spreading. Subsequent in vivo studies in rabbits demonstrated the formation of a rigid structure similar to bone trabeculae in the distal region of the tribological surface of the implant. The tribological surface of the proximal region showed a fibrocartilaginous tissue with highly vascularized chondrocytes, thus validating the proposed concept for the design of the implant incorporating a functional gradient and auto-stability.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-03T13:10:49Z
2014-12-03T13:10:49Z
2014-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-14392014005000030
Materials Research-ibero-american Journal Of Materials. Sao Carlos: Univ Fed Sao Carlos, Dept Engenharia Materials, v. 17, n. 3, p. 638-649, 2014.
1516-1439
http://hdl.handle.net/11449/112558
10.1590/S1516-14392014005000030
S1516-14392014005000030
WOS:000338017600015
S1516-14392014000300015.pdf
8379925533335630
url http://dx.doi.org/10.1590/S1516-14392014005000030
http://hdl.handle.net/11449/112558
identifier_str_mv Materials Research-ibero-american Journal Of Materials. Sao Carlos: Univ Fed Sao Carlos, Dept Engenharia Materials, v. 17, n. 3, p. 638-649, 2014.
1516-1439
10.1590/S1516-14392014005000030
S1516-14392014005000030
WOS:000338017600015
S1516-14392014000300015.pdf
8379925533335630
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials Research-ibero-american Journal of Materials
1.103
0,398
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 638-649
application/pdf
dc.publisher.none.fl_str_mv Univ Fed Sao Carlos, Dept Engenharia Materials
publisher.none.fl_str_mv Univ Fed Sao Carlos, Dept Engenharia Materials
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129539594780672

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