Evaluation of sodium diclofenac release using natural rubber latex as carrier

Detalhes bibliográficos
Autor(a) principal: Aielo,Patricia B.
Data de Publicação: 2014
Outros Autores: Borges,Felipe A., Romeira,Karoline M., Miranda,Matheus Carlos Romeiro, Arruda,Larisa B. de, L. Filho,Paulo Noronha, Drago,Bruno de C., Herculano,Rondinelli D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Materials research (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700024
Resumo: Sodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release time of diclofenac in a NRL membrane in vitro was increased from the typical 2-3 h for oral tablets to ca. 74 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 0.899 and 32.102 h. In this study, we demonstrated that the interesting properties provided by NRL membranes combined with a controlled release of drug is relevant for biomedical applications.
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spelling Evaluation of sodium diclofenac release using natural rubber latex as carriermembranesnatural rubbersodium diclofenacdrug delivery systembiomaterialsSodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release time of diclofenac in a NRL membrane in vitro was increased from the typical 2-3 h for oral tablets to ca. 74 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 0.899 and 32.102 h. In this study, we demonstrated that the interesting properties provided by NRL membranes combined with a controlled release of drug is relevant for biomedical applications.ABM, ABC, ABPol2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700024Materials Research v.17 suppl.1 2014reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/S1516-14392014005000010info:eu-repo/semantics/openAccessAielo,Patricia B.Borges,Felipe A.Romeira,Karoline M.Miranda,Matheus Carlos RomeiroArruda,Larisa B. deL. Filho,Paulo NoronhaDrago,Bruno de C.Herculano,Rondinelli D.eng2015-11-06T00:00:00Zoai:scielo:S1516-14392014000700024Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2015-11-06T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false
dc.title.none.fl_str_mv Evaluation of sodium diclofenac release using natural rubber latex as carrier
title Evaluation of sodium diclofenac release using natural rubber latex as carrier
spellingShingle Evaluation of sodium diclofenac release using natural rubber latex as carrier
Aielo,Patricia B.
membranes
natural rubber
sodium diclofenac
drug delivery system
biomaterials
title_short Evaluation of sodium diclofenac release using natural rubber latex as carrier
title_full Evaluation of sodium diclofenac release using natural rubber latex as carrier
title_fullStr Evaluation of sodium diclofenac release using natural rubber latex as carrier
title_full_unstemmed Evaluation of sodium diclofenac release using natural rubber latex as carrier
title_sort Evaluation of sodium diclofenac release using natural rubber latex as carrier
author Aielo,Patricia B.
author_facet Aielo,Patricia B.
Borges,Felipe A.
Romeira,Karoline M.
Miranda,Matheus Carlos Romeiro
Arruda,Larisa B. de
L. Filho,Paulo Noronha
Drago,Bruno de C.
Herculano,Rondinelli D.
author_role author
author2 Borges,Felipe A.
Romeira,Karoline M.
Miranda,Matheus Carlos Romeiro
Arruda,Larisa B. de
L. Filho,Paulo Noronha
Drago,Bruno de C.
Herculano,Rondinelli D.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Aielo,Patricia B.
Borges,Felipe A.
Romeira,Karoline M.
Miranda,Matheus Carlos Romeiro
Arruda,Larisa B. de
L. Filho,Paulo Noronha
Drago,Bruno de C.
Herculano,Rondinelli D.
dc.subject.por.fl_str_mv membranes
natural rubber
sodium diclofenac
drug delivery system
biomaterials
topic membranes
natural rubber
sodium diclofenac
drug delivery system
biomaterials
description Sodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release time of diclofenac in a NRL membrane in vitro was increased from the typical 2-3 h for oral tablets to ca. 74 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 0.899 and 32.102 h. In this study, we demonstrated that the interesting properties provided by NRL membranes combined with a controlled release of drug is relevant for biomedical applications.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392014000700024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-14392014005000010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv Materials Research v.17 suppl.1 2014
reponame:Materials research (São Carlos. Online)
instname:Universidade Federal de São Carlos (UFSCAR)
instacron:ABM ABC ABPOL
instname_str Universidade Federal de São Carlos (UFSCAR)
instacron_str ABM ABC ABPOL
institution ABM ABC ABPOL
reponame_str Materials research (São Carlos. Online)
collection Materials research (São Carlos. Online)
repository.name.fl_str_mv Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)
repository.mail.fl_str_mv dedz@power.ufscar.br
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