Metronidazole release using natural rubber latex as matrix

Detalhes bibliográficos
Autor(a) principal: Herculano, Rondinelli Donizetti [UNESP]
Data de Publicação: 2010
Outros Autores: Guimarães, Sérgio Augusto Catanzaro, Belmonte, Gustavo Campos, Duarte, Marco Antonio Hungaro, Oliveira Júnior, Osvaldo Novais de, Kinoshita, Angela, Graeff, Carlos Frederico de Oliveira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1516-14392010000100013
http://hdl.handle.net/11449/8405
Resumo: Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours.
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spelling Metronidazole release using natural rubber latex as matrixbiomaterialslatex membranemetronidazoledrug delivery systemNatural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)USP Instituto de Física de São Carlos Departamento de Física e Ciências dos MateriaisUniversidade do Sagrado CoraçãoUNESP Faculdade de Ciências Departamento de FísicaUNESP Faculdade de Ciências Departamento de FísicaABM, ABC, ABPolUniversidade de São Paulo (USP)Universidade do Sagrado CoraçãoUniversidade Estadual Paulista (Unesp)Herculano, Rondinelli Donizetti [UNESP]Guimarães, Sérgio Augusto CatanzaroBelmonte, Gustavo CamposDuarte, Marco Antonio HungaroOliveira Júnior, Osvaldo Novais deKinoshita, AngelaGraeff, Carlos Frederico de Oliveira [UNESP]2014-05-20T13:26:11Z2014-05-20T13:26:11Z2010-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article57-61application/pdfhttp://dx.doi.org/10.1590/S1516-14392010000100013Materials Research. ABM, ABC, ABPol, v. 13, n. 1, p. 57-61, 2010.1516-1439http://hdl.handle.net/11449/840510.1590/S1516-14392010000100013S1516-14392010000100013WOS:000276894200013S1516-14392010000100013.pdf0000-0003-0162-8273SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Research1.1030,398info:eu-repo/semantics/openAccess2024-04-25T17:40:08Zoai:repositorio.unesp.br:11449/8405Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:42.533851Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Metronidazole release using natural rubber latex as matrix
title Metronidazole release using natural rubber latex as matrix
spellingShingle Metronidazole release using natural rubber latex as matrix
Herculano, Rondinelli Donizetti [UNESP]
biomaterials
latex membrane
metronidazole
drug delivery system
title_short Metronidazole release using natural rubber latex as matrix
title_full Metronidazole release using natural rubber latex as matrix
title_fullStr Metronidazole release using natural rubber latex as matrix
title_full_unstemmed Metronidazole release using natural rubber latex as matrix
title_sort Metronidazole release using natural rubber latex as matrix
author Herculano, Rondinelli Donizetti [UNESP]
author_facet Herculano, Rondinelli Donizetti [UNESP]
Guimarães, Sérgio Augusto Catanzaro
Belmonte, Gustavo Campos
Duarte, Marco Antonio Hungaro
Oliveira Júnior, Osvaldo Novais de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira [UNESP]
author_role author
author2 Guimarães, Sérgio Augusto Catanzaro
Belmonte, Gustavo Campos
Duarte, Marco Antonio Hungaro
Oliveira Júnior, Osvaldo Novais de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade do Sagrado Coração
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Herculano, Rondinelli Donizetti [UNESP]
Guimarães, Sérgio Augusto Catanzaro
Belmonte, Gustavo Campos
Duarte, Marco Antonio Hungaro
Oliveira Júnior, Osvaldo Novais de
Kinoshita, Angela
Graeff, Carlos Frederico de Oliveira [UNESP]
dc.subject.por.fl_str_mv biomaterials
latex membrane
metronidazole
drug delivery system
topic biomaterials
latex membrane
metronidazole
drug delivery system
description Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
2014-05-20T13:26:11Z
2014-05-20T13:26:11Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-14392010000100013
Materials Research. ABM, ABC, ABPol, v. 13, n. 1, p. 57-61, 2010.
1516-1439
http://hdl.handle.net/11449/8405
10.1590/S1516-14392010000100013
S1516-14392010000100013
WOS:000276894200013
S1516-14392010000100013.pdf
0000-0003-0162-8273
url http://dx.doi.org/10.1590/S1516-14392010000100013
http://hdl.handle.net/11449/8405
identifier_str_mv Materials Research. ABM, ABC, ABPol, v. 13, n. 1, p. 57-61, 2010.
1516-1439
10.1590/S1516-14392010000100013
S1516-14392010000100013
WOS:000276894200013
S1516-14392010000100013.pdf
0000-0003-0162-8273
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials Research
1.103
0,398
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 57-61
application/pdf
dc.publisher.none.fl_str_mv ABM, ABC, ABPol
publisher.none.fl_str_mv ABM, ABC, ABPol
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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