Metronidazole release using natural rubber latex as matrix
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1516-14392010000100013 http://hdl.handle.net/11449/8405 |
Resumo: | Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours. |
id |
UNSP_b52bb79711e8cbdefcf36b5829fb8efd |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/8405 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Metronidazole release using natural rubber latex as matrixbiomaterialslatex membranemetronidazoledrug delivery systemNatural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)USP Instituto de Física de São Carlos Departamento de Física e Ciências dos MateriaisUniversidade do Sagrado CoraçãoUNESP Faculdade de Ciências Departamento de FísicaUNESP Faculdade de Ciências Departamento de FísicaABM, ABC, ABPolUniversidade de São Paulo (USP)Universidade do Sagrado CoraçãoUniversidade Estadual Paulista (Unesp)Herculano, Rondinelli Donizetti [UNESP]Guimarães, Sérgio Augusto CatanzaroBelmonte, Gustavo CamposDuarte, Marco Antonio HungaroOliveira Júnior, Osvaldo Novais deKinoshita, AngelaGraeff, Carlos Frederico de Oliveira [UNESP]2014-05-20T13:26:11Z2014-05-20T13:26:11Z2010-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article57-61application/pdfhttp://dx.doi.org/10.1590/S1516-14392010000100013Materials Research. ABM, ABC, ABPol, v. 13, n. 1, p. 57-61, 2010.1516-1439http://hdl.handle.net/11449/840510.1590/S1516-14392010000100013S1516-14392010000100013WOS:000276894200013S1516-14392010000100013.pdf0000-0003-0162-8273SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Research1.1030,398info:eu-repo/semantics/openAccess2024-04-25T17:40:08Zoai:repositorio.unesp.br:11449/8405Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:42.533851Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Metronidazole release using natural rubber latex as matrix |
title |
Metronidazole release using natural rubber latex as matrix |
spellingShingle |
Metronidazole release using natural rubber latex as matrix Herculano, Rondinelli Donizetti [UNESP] biomaterials latex membrane metronidazole drug delivery system |
title_short |
Metronidazole release using natural rubber latex as matrix |
title_full |
Metronidazole release using natural rubber latex as matrix |
title_fullStr |
Metronidazole release using natural rubber latex as matrix |
title_full_unstemmed |
Metronidazole release using natural rubber latex as matrix |
title_sort |
Metronidazole release using natural rubber latex as matrix |
author |
Herculano, Rondinelli Donizetti [UNESP] |
author_facet |
Herculano, Rondinelli Donizetti [UNESP] Guimarães, Sérgio Augusto Catanzaro Belmonte, Gustavo Campos Duarte, Marco Antonio Hungaro Oliveira Júnior, Osvaldo Novais de Kinoshita, Angela Graeff, Carlos Frederico de Oliveira [UNESP] |
author_role |
author |
author2 |
Guimarães, Sérgio Augusto Catanzaro Belmonte, Gustavo Campos Duarte, Marco Antonio Hungaro Oliveira Júnior, Osvaldo Novais de Kinoshita, Angela Graeff, Carlos Frederico de Oliveira [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade do Sagrado Coração Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Herculano, Rondinelli Donizetti [UNESP] Guimarães, Sérgio Augusto Catanzaro Belmonte, Gustavo Campos Duarte, Marco Antonio Hungaro Oliveira Júnior, Osvaldo Novais de Kinoshita, Angela Graeff, Carlos Frederico de Oliveira [UNESP] |
dc.subject.por.fl_str_mv |
biomaterials latex membrane metronidazole drug delivery system |
topic |
biomaterials latex membrane metronidazole drug delivery system |
description |
Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-03-01 2014-05-20T13:26:11Z 2014-05-20T13:26:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1516-14392010000100013 Materials Research. ABM, ABC, ABPol, v. 13, n. 1, p. 57-61, 2010. 1516-1439 http://hdl.handle.net/11449/8405 10.1590/S1516-14392010000100013 S1516-14392010000100013 WOS:000276894200013 S1516-14392010000100013.pdf 0000-0003-0162-8273 |
url |
http://dx.doi.org/10.1590/S1516-14392010000100013 http://hdl.handle.net/11449/8405 |
identifier_str_mv |
Materials Research. ABM, ABC, ABPol, v. 13, n. 1, p. 57-61, 2010. 1516-1439 10.1590/S1516-14392010000100013 S1516-14392010000100013 WOS:000276894200013 S1516-14392010000100013.pdf 0000-0003-0162-8273 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials Research 1.103 0,398 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
57-61 application/pdf |
dc.publisher.none.fl_str_mv |
ABM, ABC, ABPol |
publisher.none.fl_str_mv |
ABM, ABC, ABPol |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129136124755968 |