Behavioral investigation of mice with experimental autoimmune encephalomyelitis

• Autor(a) principal: Rodrigues,David Henrique
• Data de Publicação: 2011
• Outros Autores: Vilela,Márcia de Carvalho, Lacerda-Queiroz,Norinne, Miranda,Aline Silva de, Sousa,Larissa Fonseca da Cunha, Reis,Helton José dos, Teixeira,Antônio Lúcio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000700018
• topic: multiple sclerosis; experimental autoimune encephalomyelitis; behavior; memory; anxiety

Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG35-55 model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG35-55 are probably subtle or absent.