Botulinum toxin A in the treatment of blepharospasm: a 10-year experience

Detalhes bibliográficos
Autor(a) principal: Silveira-Moriyama,Laura
Data de Publicação: 2005
Outros Autores: Gonçalves,Lilian R., Chien,Hsin Fen, Barbosa,Egberto R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200006
Resumo: To evaluate the long-term effect of botulinum toxin type A (BTX) in the treatment of blepharospasm, a retrospective analysis was conducted from the patients seen at the Movement Disorders Clinic of the Department of Neurology, Hospital das Clínicas, University of São Paulo School of Medicine from 1993 to 2003. A total of 379 treatments with BTX were administered to 30 patients with blepharospasm. Sixty six per cent of the subjects had used oral medication for dystonia and only 15% of them reported satisfactory response to this treatment. Ninety three per cent of the patients showed significant improvement after the first BTX injection. There was no decrement in response when compared the first and the last injection recorded. Adverse effects, mostly minor, developed at least once in 53% of patients. Six patients (20%) discontinued the treatment but there was no case of secondary resistance.
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spelling Botulinum toxin A in the treatment of blepharospasm: a 10-year experiencebotulinum toxinblepharospasmdystoniaTo evaluate the long-term effect of botulinum toxin type A (BTX) in the treatment of blepharospasm, a retrospective analysis was conducted from the patients seen at the Movement Disorders Clinic of the Department of Neurology, Hospital das Clínicas, University of São Paulo School of Medicine from 1993 to 2003. A total of 379 treatments with BTX were administered to 30 patients with blepharospasm. Sixty six per cent of the subjects had used oral medication for dystonia and only 15% of them reported satisfactory response to this treatment. Ninety three per cent of the patients showed significant improvement after the first BTX injection. There was no decrement in response when compared the first and the last injection recorded. Adverse effects, mostly minor, developed at least once in 53% of patients. Six patients (20%) discontinued the treatment but there was no case of secondary resistance.Academia Brasileira de Neurologia - ABNEURO2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200006Arquivos de Neuro-Psiquiatria v.63 n.2a 2005reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2005000200006info:eu-repo/semantics/openAccessSilveira-Moriyama,LauraGonçalves,Lilian R.Chien,Hsin FenBarbosa,Egberto R.eng2005-07-05T00:00:00Zoai:scielo:S0004-282X2005000200006Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2005-07-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
title Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
spellingShingle Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
Silveira-Moriyama,Laura
botulinum toxin
blepharospasm
dystonia
title_short Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
title_full Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
title_fullStr Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
title_full_unstemmed Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
title_sort Botulinum toxin A in the treatment of blepharospasm: a 10-year experience
author Silveira-Moriyama,Laura
author_facet Silveira-Moriyama,Laura
Gonçalves,Lilian R.
Chien,Hsin Fen
Barbosa,Egberto R.
author_role author
author2 Gonçalves,Lilian R.
Chien,Hsin Fen
Barbosa,Egberto R.
author2_role author
author
author
dc.contributor.author.fl_str_mv Silveira-Moriyama,Laura
Gonçalves,Lilian R.
Chien,Hsin Fen
Barbosa,Egberto R.
dc.subject.por.fl_str_mv botulinum toxin
blepharospasm
dystonia
topic botulinum toxin
blepharospasm
dystonia
description To evaluate the long-term effect of botulinum toxin type A (BTX) in the treatment of blepharospasm, a retrospective analysis was conducted from the patients seen at the Movement Disorders Clinic of the Department of Neurology, Hospital das Clínicas, University of São Paulo School of Medicine from 1993 to 2003. A total of 379 treatments with BTX were administered to 30 patients with blepharospasm. Sixty six per cent of the subjects had used oral medication for dystonia and only 15% of them reported satisfactory response to this treatment. Ninety three per cent of the patients showed significant improvement after the first BTX injection. There was no decrement in response when compared the first and the last injection recorded. Adverse effects, mostly minor, developed at least once in 53% of patients. Six patients (20%) discontinued the treatment but there was no case of secondary resistance.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000200006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2005000200006
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.63 n.2a 2005
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
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institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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