Botulinum toxin type A and cervical dystonia: a seven-year follow-up
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600004 |
Resumo: | Most cases of cervical dystonia (CD) are idiopathic, and focal injections of botulinum toxin A (BoNT/A) are the treatment of choice. The objective of our study was to document the effects of long-term BoNT/A treatment in idiopathic CD patients. Fifty-eight patients with idiopathic CD were recruited from March 2001 to May 2002. Twenty-eight of the subjects were available for reassessment after seven years. During this period, all had received regular treatment with BoNT/A injections. Clinical information about patients and the severity of CD (TWSTRS and VAPS) at baseline assessment (2001-2002) and follow-up (2008-2009) was compared. Significant motor improvement was detected based on TWSTRS scale scores, which were used to analyze clinical severity (19.6±6.6 and 17.7±4.8; p<0.05). There was no improvement in the severity of cervical pain (p=0.43). In conclusion, BoNT/A was a safe and effective long-term therapy for CD. |
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Botulinum toxin type A and cervical dystonia: a seven-year follow-upcervical dystoniabotulinum toxindysphagiaMost cases of cervical dystonia (CD) are idiopathic, and focal injections of botulinum toxin A (BoNT/A) are the treatment of choice. The objective of our study was to document the effects of long-term BoNT/A treatment in idiopathic CD patients. Fifty-eight patients with idiopathic CD were recruited from March 2001 to May 2002. Twenty-eight of the subjects were available for reassessment after seven years. During this period, all had received regular treatment with BoNT/A injections. Clinical information about patients and the severity of CD (TWSTRS and VAPS) at baseline assessment (2001-2002) and follow-up (2008-2009) was compared. Significant motor improvement was detected based on TWSTRS scale scores, which were used to analyze clinical severity (19.6±6.6 and 17.7±4.8; p<0.05). There was no improvement in the severity of cervical pain (p=0.43). In conclusion, BoNT/A was a safe and effective long-term therapy for CD.Academia Brasileira de Neurologia - ABNEURO2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600004Arquivos de Neuro-Psiquiatria v.69 n.5 2011reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2011000600004info:eu-repo/semantics/openAccessCamargo,Carlos Henrique F.Teive,Hélio Afonso G.Becker,NilsonMunhoz,Renato P.Werneck,Lineu Césareng2011-10-27T00:00:00Zoai:scielo:S0004-282X2011000600004Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2011-10-27T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
title |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
spellingShingle |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up Camargo,Carlos Henrique F. cervical dystonia botulinum toxin dysphagia |
title_short |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
title_full |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
title_fullStr |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
title_full_unstemmed |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
title_sort |
Botulinum toxin type A and cervical dystonia: a seven-year follow-up |
author |
Camargo,Carlos Henrique F. |
author_facet |
Camargo,Carlos Henrique F. Teive,Hélio Afonso G. Becker,Nilson Munhoz,Renato P. Werneck,Lineu César |
author_role |
author |
author2 |
Teive,Hélio Afonso G. Becker,Nilson Munhoz,Renato P. Werneck,Lineu César |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Camargo,Carlos Henrique F. Teive,Hélio Afonso G. Becker,Nilson Munhoz,Renato P. Werneck,Lineu César |
dc.subject.por.fl_str_mv |
cervical dystonia botulinum toxin dysphagia |
topic |
cervical dystonia botulinum toxin dysphagia |
description |
Most cases of cervical dystonia (CD) are idiopathic, and focal injections of botulinum toxin A (BoNT/A) are the treatment of choice. The objective of our study was to document the effects of long-term BoNT/A treatment in idiopathic CD patients. Fifty-eight patients with idiopathic CD were recruited from March 2001 to May 2002. Twenty-eight of the subjects were available for reassessment after seven years. During this period, all had received regular treatment with BoNT/A injections. Clinical information about patients and the severity of CD (TWSTRS and VAPS) at baseline assessment (2001-2002) and follow-up (2008-2009) was compared. Significant motor improvement was detected based on TWSTRS scale scores, which were used to analyze clinical severity (19.6±6.6 and 17.7±4.8; p<0.05). There was no improvement in the severity of cervical pain (p=0.43). In conclusion, BoNT/A was a safe and effective long-term therapy for CD. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000600004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2011000600004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.69 n.5 2011 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212771600269312 |