Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease

Detalhes bibliográficos
Autor(a) principal: Smid,Jerusa
Data de Publicação: 2013
Outros Autores: Landemberger,Michele Christine, Bahia,Valéria Santoro, Martins,Vilma Regina, Nitrini,Ricardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700423
Resumo: Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD).ObjectiveTo describe the association between codon 129 polymorphisms and AD.MethodsWe investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated.ResultsCodon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p>0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups.ConclusionCodon 129 polymorphism is not a risk factor for AD in Brazilian patients.
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spelling Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's diseaseprion protein geneAlzheimer's diseasepolymorphismcodon 129cognitive performanceapolipoprotein E geneInteraction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD).ObjectiveTo describe the association between codon 129 polymorphisms and AD.MethodsWe investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated.ResultsCodon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p>0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups.ConclusionCodon 129 polymorphism is not a risk factor for AD in Brazilian patients.Academia Brasileira de Neurologia - ABNEURO2013-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700423Arquivos de Neuro-Psiquiatria v.71 n.7 2013reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130055info:eu-repo/semantics/openAccessSmid,JerusaLandemberger,Michele ChristineBahia,Valéria SantoroMartins,Vilma ReginaNitrini,Ricardoeng2015-10-23T00:00:00Zoai:scielo:S0004-282X2013000700423Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2015-10-23T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
title Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
spellingShingle Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
Smid,Jerusa
prion protein gene
Alzheimer's disease
polymorphism
codon 129
cognitive performance
apolipoprotein E gene
title_short Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
title_full Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
title_fullStr Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
title_full_unstemmed Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
title_sort Codon 129 polymorphism of prion protein gene in is not a risk factor for Alzheimer's disease
author Smid,Jerusa
author_facet Smid,Jerusa
Landemberger,Michele Christine
Bahia,Valéria Santoro
Martins,Vilma Regina
Nitrini,Ricardo
author_role author
author2 Landemberger,Michele Christine
Bahia,Valéria Santoro
Martins,Vilma Regina
Nitrini,Ricardo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Smid,Jerusa
Landemberger,Michele Christine
Bahia,Valéria Santoro
Martins,Vilma Regina
Nitrini,Ricardo
dc.subject.por.fl_str_mv prion protein gene
Alzheimer's disease
polymorphism
codon 129
cognitive performance
apolipoprotein E gene
topic prion protein gene
Alzheimer's disease
polymorphism
codon 129
cognitive performance
apolipoprotein E gene
description Interaction of prion protein and amyloid-b oligomers has been demonstrated recently. Homozygosity at prion protein gene (PRNP) codon 129 is associated with higher risk for Creutzfeldt-Jakob disease. This polymorphism has been addressed as a possible risk factor in Alzheimer disease (AD).ObjectiveTo describe the association between codon 129 polymorphisms and AD.MethodsWe investigated the association of codon 129 polymorphism of PRNP in 99 AD patients and 111 controls, and the association between this polymorphism and cognitive performance. Other polymorphisms of PRNP and additive effect of apolipoprotein E gene (ApoE) were evaluated.ResultsCodon 129 genotype distribution in AD 45.5% methionine (MM), 42.2% methionine valine (MV), 12.1% valine (VV); and 39.6% MM, 50.5% MV, 9.9% VV among controls (p>0.05). There were no differences of cognitive performance concerning codon 129. Stratification according to ApoE genotype did not reveal difference between groups.ConclusionCodon 129 polymorphism is not a risk factor for AD in Brazilian patients.
publishDate 2013
dc.date.none.fl_str_mv 2013-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700423
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013000700423
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20130055
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.71 n.7 2013
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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