Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

Detalhes bibliográficos
Autor(a) principal: Brenna,Sylvia Michelina Fernandes
Data de Publicação: 2004
Outros Autores: Silva,Ismael Dale Cotrin Guerreiro da, Zeferino,Luiz Carlos, Pereira,Julia, Martinez,Edson Zachaione, Syrjänen,Kari Juhani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400005
Resumo: The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
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spelling Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancerp53 polymorphismcodon 72genetic polymorphismcervix cancerhuman papillomavirusThe p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.Sociedade Brasileira de Genética2004-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400005Genetics and Molecular Biology v.27 n.4 2004reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572004000400005info:eu-repo/semantics/openAccessBrenna,Sylvia Michelina FernandesSilva,Ismael Dale Cotrin Guerreiro daZeferino,Luiz CarlosPereira,JuliaMartinez,Edson ZachaioneSyrjänen,Kari Juhanieng2005-01-14T00:00:00Zoai:scielo:S1415-47572004000400005Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2005-01-14T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
spellingShingle Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
Brenna,Sylvia Michelina Fernandes
p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
title_short Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_full Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_fullStr Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_full_unstemmed Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
title_sort Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer
author Brenna,Sylvia Michelina Fernandes
author_facet Brenna,Sylvia Michelina Fernandes
Silva,Ismael Dale Cotrin Guerreiro da
Zeferino,Luiz Carlos
Pereira,Julia
Martinez,Edson Zachaione
Syrjänen,Kari Juhani
author_role author
author2 Silva,Ismael Dale Cotrin Guerreiro da
Zeferino,Luiz Carlos
Pereira,Julia
Martinez,Edson Zachaione
Syrjänen,Kari Juhani
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Brenna,Sylvia Michelina Fernandes
Silva,Ismael Dale Cotrin Guerreiro da
Zeferino,Luiz Carlos
Pereira,Julia
Martinez,Edson Zachaione
Syrjänen,Kari Juhani
dc.subject.por.fl_str_mv p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
topic p53 polymorphism
codon 72
genetic polymorphism
cervix cancer
human papillomavirus
description The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572004000400005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.27 n.4 2004
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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