Neurological disorders associated with glutamic acid decarboxylase antibodies: a Brazilian series

• Autor(a) principal: Fernandes,Maurício
• Data de Publicação: 2012
• Outros Autores: Munhoz,Renato P., Carrilho,Paulo Eduardo Mestrinelli, Arruda,Walter O., Lorenzoni,Paulo J., Scola,Rosana H., Werneck,Lineu César, Teive,Hélio A. G.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de neuro-psiquiatria (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000900002
• topic: glutamic acid decarboxylase antibodies; anti-GAD; neurological disorders; stiff-person syndrome; cerebellar ataxia

Neurological disorders associated with glutamic acid decarboxylase (GAD) antibodies are rare pleomorphic diseases of uncertain cause, of which stiff-person syndrome (SPS) is the best-known. Here, we described nine consecutive cases of neurological disorders associated with anti-GAD, including nine patients with SPS and three cases with cerebellar ataxia. Additionally, four had hypothyroidism, three epilepsy, two diabetes mellitus and two axial myoclonus.