Functional evaluation of temporary focal cerebral ischemia: experimental model

Detalhes bibliográficos
Autor(a) principal: Duarte,Sinésio Grace
Data de Publicação: 2003
Outros Autores: Campos,Antônio Dorival, Colli,Benedicto Oscar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500009
Resumo: OBJECTIVE: Despite cerebral ischemia being a frequent clinical pathologic state, the tolerance of neural tissue to oxygen absence and to reperfusion is controversial. This study aims to evaluate the effects of focal cerebral ischemia/reperfusion, by analyzing the mitochondrial respiration. METHOD: Sixty-four adult rats underwent focal cerebral ischemia by middle cerebral artery occlusion, during 15, 30 and 60 minutes, followed by 10 minutes or 19 hours of reperfusion. The effects of ischemia were analyzed measuring the O2 consumption by mitochondria in the ischemic and non-ischemic areas. RESULTS: There was compromise of the mitochondrial respiration after 30 and 60 minutes of ischemia, followed by 10 minutes of reperfusion but there was no alteration in this function after 19 hours of reperfusion. CONCLUSION: Compromise of the mitochondrial function occurred after 30 minutes of ischemia but, until one hour of ischemia, if the reperfusion was prolonged there was no evidence of ischemic/reperfusion injuries.
id ABNEURO-1_239bcfbee06eeeab8c47825cd7ac19f5
oai_identifier_str oai:scielo:S0004-282X2003000500009
network_acronym_str ABNEURO-1
network_name_str Arquivos de neuro-psiquiatria (Online)
repository_id_str
spelling Functional evaluation of temporary focal cerebral ischemia: experimental modelfocal brain ischemiareperfusionmitochondrial respirationOBJECTIVE: Despite cerebral ischemia being a frequent clinical pathologic state, the tolerance of neural tissue to oxygen absence and to reperfusion is controversial. This study aims to evaluate the effects of focal cerebral ischemia/reperfusion, by analyzing the mitochondrial respiration. METHOD: Sixty-four adult rats underwent focal cerebral ischemia by middle cerebral artery occlusion, during 15, 30 and 60 minutes, followed by 10 minutes or 19 hours of reperfusion. The effects of ischemia were analyzed measuring the O2 consumption by mitochondria in the ischemic and non-ischemic areas. RESULTS: There was compromise of the mitochondrial respiration after 30 and 60 minutes of ischemia, followed by 10 minutes of reperfusion but there was no alteration in this function after 19 hours of reperfusion. CONCLUSION: Compromise of the mitochondrial function occurred after 30 minutes of ischemia but, until one hour of ischemia, if the reperfusion was prolonged there was no evidence of ischemic/reperfusion injuries.Academia Brasileira de Neurologia - ABNEURO2003-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500009Arquivos de Neuro-Psiquiatria v.61 n.3B 2003reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2003000500009info:eu-repo/semantics/openAccessDuarte,Sinésio GraceCampos,Antônio DorivalColli,Benedicto Oscareng2003-11-12T00:00:00Zoai:scielo:S0004-282X2003000500009Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2003-11-12T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Functional evaluation of temporary focal cerebral ischemia: experimental model
title Functional evaluation of temporary focal cerebral ischemia: experimental model
spellingShingle Functional evaluation of temporary focal cerebral ischemia: experimental model
Duarte,Sinésio Grace
focal brain ischemia
reperfusion
mitochondrial respiration
title_short Functional evaluation of temporary focal cerebral ischemia: experimental model
title_full Functional evaluation of temporary focal cerebral ischemia: experimental model
title_fullStr Functional evaluation of temporary focal cerebral ischemia: experimental model
title_full_unstemmed Functional evaluation of temporary focal cerebral ischemia: experimental model
title_sort Functional evaluation of temporary focal cerebral ischemia: experimental model
author Duarte,Sinésio Grace
author_facet Duarte,Sinésio Grace
Campos,Antônio Dorival
Colli,Benedicto Oscar
author_role author
author2 Campos,Antônio Dorival
Colli,Benedicto Oscar
author2_role author
author
dc.contributor.author.fl_str_mv Duarte,Sinésio Grace
Campos,Antônio Dorival
Colli,Benedicto Oscar
dc.subject.por.fl_str_mv focal brain ischemia
reperfusion
mitochondrial respiration
topic focal brain ischemia
reperfusion
mitochondrial respiration
description OBJECTIVE: Despite cerebral ischemia being a frequent clinical pathologic state, the tolerance of neural tissue to oxygen absence and to reperfusion is controversial. This study aims to evaluate the effects of focal cerebral ischemia/reperfusion, by analyzing the mitochondrial respiration. METHOD: Sixty-four adult rats underwent focal cerebral ischemia by middle cerebral artery occlusion, during 15, 30 and 60 minutes, followed by 10 minutes or 19 hours of reperfusion. The effects of ischemia were analyzed measuring the O2 consumption by mitochondria in the ischemic and non-ischemic areas. RESULTS: There was compromise of the mitochondrial respiration after 30 and 60 minutes of ischemia, followed by 10 minutes of reperfusion but there was no alteration in this function after 19 hours of reperfusion. CONCLUSION: Compromise of the mitochondrial function occurred after 30 minutes of ischemia but, until one hour of ischemia, if the reperfusion was prolonged there was no evidence of ischemic/reperfusion injuries.
publishDate 2003
dc.date.none.fl_str_mv 2003-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000500009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2003000500009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.61 n.3B 2003
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
_version_ 1754212755780403200

Registros relacionados