Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia

Detalhes bibliográficos
Autor(a) principal: Silva,Manoel Nunes da
Data de Publicação: 2007
Outros Autores: Colli,Benedicto Oscar, Coimbra,Norberto Cysne, Coutinho Netto,Joaquim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011
Resumo: OBJECTIVE: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen. METHOD: One-hundred-and-three Wistar rats divided into groups A and B were respectively submitted to 48 hours and 15 days of ischemia. Each group was divided into 4 subgroups: ischemic not treated, ischemic treated, sham not treated, and sham treated. Ischemic animals had the left middle cerebral artery coagulated. Ketoprofen was administered to treated subgroups 15 minutes before arterial coagulation (manipulation in the sham group). RESULTS: Exploratory activity and defecation were reduced in all ischemic animals in the first postoperative days and constant histopathological changes were observed in each group. The total brain glutamate levels were higher in treated animals 48 hours after surgery. CONCLUSION: No clear parallelism among behavioral, biochemical and histopathological findings was observed. Ketoprofen demonstrated no neuroprotective effect on the behavioral or histopathological aspects of focal permanent brain ischemia.
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spelling Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemiafocal brain ischemiaratopen fieldglutamatehistopathologyneuroprotectionketoprofenOBJECTIVE: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen. METHOD: One-hundred-and-three Wistar rats divided into groups A and B were respectively submitted to 48 hours and 15 days of ischemia. Each group was divided into 4 subgroups: ischemic not treated, ischemic treated, sham not treated, and sham treated. Ischemic animals had the left middle cerebral artery coagulated. Ketoprofen was administered to treated subgroups 15 minutes before arterial coagulation (manipulation in the sham group). RESULTS: Exploratory activity and defecation were reduced in all ischemic animals in the first postoperative days and constant histopathological changes were observed in each group. The total brain glutamate levels were higher in treated animals 48 hours after surgery. CONCLUSION: No clear parallelism among behavioral, biochemical and histopathological findings was observed. Ketoprofen demonstrated no neuroprotective effect on the behavioral or histopathological aspects of focal permanent brain ischemia.Academia Brasileira de Neurologia - ABNEURO2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011Arquivos de Neuro-Psiquiatria v.65 n.4a 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000600011info:eu-repo/semantics/openAccessSilva,Manoel Nunes daColli,Benedicto OscarCoimbra,Norberto CysneCoutinho Netto,Joaquimeng2007-12-06T00:00:00Zoai:scielo:S0004-282X2007000600011Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2007-12-06T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
title Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
spellingShingle Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
Silva,Manoel Nunes da
focal brain ischemia
rat
open field
glutamate
histopathology
neuroprotection
ketoprofen
title_short Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
title_full Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
title_fullStr Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
title_full_unstemmed Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
title_sort Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
author Silva,Manoel Nunes da
author_facet Silva,Manoel Nunes da
Colli,Benedicto Oscar
Coimbra,Norberto Cysne
Coutinho Netto,Joaquim
author_role author
author2 Colli,Benedicto Oscar
Coimbra,Norberto Cysne
Coutinho Netto,Joaquim
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Manoel Nunes da
Colli,Benedicto Oscar
Coimbra,Norberto Cysne
Coutinho Netto,Joaquim
dc.subject.por.fl_str_mv focal brain ischemia
rat
open field
glutamate
histopathology
neuroprotection
ketoprofen
topic focal brain ischemia
rat
open field
glutamate
histopathology
neuroprotection
ketoprofen
description OBJECTIVE: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen. METHOD: One-hundred-and-three Wistar rats divided into groups A and B were respectively submitted to 48 hours and 15 days of ischemia. Each group was divided into 4 subgroups: ischemic not treated, ischemic treated, sham not treated, and sham treated. Ischemic animals had the left middle cerebral artery coagulated. Ketoprofen was administered to treated subgroups 15 minutes before arterial coagulation (manipulation in the sham group). RESULTS: Exploratory activity and defecation were reduced in all ischemic animals in the first postoperative days and constant histopathological changes were observed in each group. The total brain glutamate levels were higher in treated animals 48 hours after surgery. CONCLUSION: No clear parallelism among behavioral, biochemical and histopathological findings was observed. Ketoprofen demonstrated no neuroprotective effect on the behavioral or histopathological aspects of focal permanent brain ischemia.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2007000600011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.65 n.4a 2007
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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