Mary Broadfoot Walker: 83 years since a historical discovery
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017001100825 |
Resumo: | ABSTRACT Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease. |
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Mary Broadfoot Walker: 83 years since a historical discoverymyasthenia gravisphysostigmineneostigmineacetylcholinesteraseABSTRACT Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease.Academia Brasileira de Neurologia - ABNEURO2017-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017001100825Arquivos de Neuro-Psiquiatria v.75 n.11 2017reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20170138info:eu-repo/semantics/openAccessCarvalho,Vitor Martinez deNogueira,Eduardo de Almeida GuimarãesRosa,Gleysson RodriguesFragoso,Yara Dadaltieng2017-12-05T00:00:00Zoai:scielo:S0004-282X2017001100825Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2017-12-05T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Mary Broadfoot Walker: 83 years since a historical discovery |
title |
Mary Broadfoot Walker: 83 years since a historical discovery |
spellingShingle |
Mary Broadfoot Walker: 83 years since a historical discovery Carvalho,Vitor Martinez de myasthenia gravis physostigmine neostigmine acetylcholinesterase |
title_short |
Mary Broadfoot Walker: 83 years since a historical discovery |
title_full |
Mary Broadfoot Walker: 83 years since a historical discovery |
title_fullStr |
Mary Broadfoot Walker: 83 years since a historical discovery |
title_full_unstemmed |
Mary Broadfoot Walker: 83 years since a historical discovery |
title_sort |
Mary Broadfoot Walker: 83 years since a historical discovery |
author |
Carvalho,Vitor Martinez de |
author_facet |
Carvalho,Vitor Martinez de Nogueira,Eduardo de Almeida Guimarães Rosa,Gleysson Rodrigues Fragoso,Yara Dadalti |
author_role |
author |
author2 |
Nogueira,Eduardo de Almeida Guimarães Rosa,Gleysson Rodrigues Fragoso,Yara Dadalti |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Carvalho,Vitor Martinez de Nogueira,Eduardo de Almeida Guimarães Rosa,Gleysson Rodrigues Fragoso,Yara Dadalti |
dc.subject.por.fl_str_mv |
myasthenia gravis physostigmine neostigmine acetylcholinesterase |
topic |
myasthenia gravis physostigmine neostigmine acetylcholinesterase |
description |
ABSTRACT Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017001100825 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017001100825 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20170138 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.75 n.11 2017 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212783158722560 |