Beta interferons in clinically isolated syndromes: a meta-analysis

Detalhes bibliográficos
Autor(a) principal: Melo,Ailton
Data de Publicação: 2008
Outros Autores: Rodrigues,Bernardo, Bar-Or,Amit
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000100003
Resumo: Beta-interferon use in definite multiple sclerosis (MS) has been proven to modify clinical and magnetic resonance imaging outcome. We review and summarize the data of published double-blind, randomized clinical trials to assess, with a meta-analysis the safety and efficacy of beta-interferon on the occurrence of relapses in patients with a first clinical event suggestive of MS. After two years of follow-up, interferon beta decreased the risk of conversion to clinically definite MS 0.51[0.39-0.65], and delayed the time to diagnosis up to 367 days. Side-effects were mild and self limited. Our findings support the efficacy of early treatment with beta-interferon in reducing conversion to clinically defined MS in patients with clinically isolated syndromes.
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spelling Beta interferons in clinically isolated syndromes: a meta-analysisinterferonclinically isolated syndromesmultiple sclerosisimmunomodulating therapyBeta-interferon use in definite multiple sclerosis (MS) has been proven to modify clinical and magnetic resonance imaging outcome. We review and summarize the data of published double-blind, randomized clinical trials to assess, with a meta-analysis the safety and efficacy of beta-interferon on the occurrence of relapses in patients with a first clinical event suggestive of MS. After two years of follow-up, interferon beta decreased the risk of conversion to clinically definite MS 0.51[0.39-0.65], and delayed the time to diagnosis up to 367 days. Side-effects were mild and self limited. Our findings support the efficacy of early treatment with beta-interferon in reducing conversion to clinically defined MS in patients with clinically isolated syndromes.Academia Brasileira de Neurologia - ABNEURO2008-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000100003Arquivos de Neuro-Psiquiatria v.66 n.1 2008reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2008000100003info:eu-repo/semantics/openAccessMelo,AiltonRodrigues,BernardoBar-Or,Amiteng2008-03-28T00:00:00Zoai:scielo:S0004-282X2008000100003Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2008-03-28T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Beta interferons in clinically isolated syndromes: a meta-analysis
title Beta interferons in clinically isolated syndromes: a meta-analysis
spellingShingle Beta interferons in clinically isolated syndromes: a meta-analysis
Melo,Ailton
interferon
clinically isolated syndromes
multiple sclerosis
immunomodulating therapy
title_short Beta interferons in clinically isolated syndromes: a meta-analysis
title_full Beta interferons in clinically isolated syndromes: a meta-analysis
title_fullStr Beta interferons in clinically isolated syndromes: a meta-analysis
title_full_unstemmed Beta interferons in clinically isolated syndromes: a meta-analysis
title_sort Beta interferons in clinically isolated syndromes: a meta-analysis
author Melo,Ailton
author_facet Melo,Ailton
Rodrigues,Bernardo
Bar-Or,Amit
author_role author
author2 Rodrigues,Bernardo
Bar-Or,Amit
author2_role author
author
dc.contributor.author.fl_str_mv Melo,Ailton
Rodrigues,Bernardo
Bar-Or,Amit
dc.subject.por.fl_str_mv interferon
clinically isolated syndromes
multiple sclerosis
immunomodulating therapy
topic interferon
clinically isolated syndromes
multiple sclerosis
immunomodulating therapy
description Beta-interferon use in definite multiple sclerosis (MS) has been proven to modify clinical and magnetic resonance imaging outcome. We review and summarize the data of published double-blind, randomized clinical trials to assess, with a meta-analysis the safety and efficacy of beta-interferon on the occurrence of relapses in patients with a first clinical event suggestive of MS. After two years of follow-up, interferon beta decreased the risk of conversion to clinically definite MS 0.51[0.39-0.65], and delayed the time to diagnosis up to 367 days. Side-effects were mild and self limited. Our findings support the efficacy of early treatment with beta-interferon in reducing conversion to clinically defined MS in patients with clinically isolated syndromes.
publishDate 2008
dc.date.none.fl_str_mv 2008-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2008000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.66 n.1 2008
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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